Home Tools
Log in
Cart

Furosemide sodium

Catalog No. T35336   CAS 41733-55-5
Synonyms: Frusemide Sodium, Lasix

Furosemide sodium (Frusemide Sodium) is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Furosemide sodium Chemical Structure
Furosemide sodium, CAS 41733-55-5
Pack Size Availability Price/USD Quantity
25 mg In stock $ 29.00
1 mL * 10 mM (in DMSO) In stock $ 79.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 100%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description Furosemide sodium (Frusemide Sodium) is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema.
Targets&IC50 NKCC:, GABAA receptor:
In vitro Furosemide sodium, at a concentration of 500 µM administered over 72-96 hours, significantly alters the proliferation rates of MKN45 cells, a poorly differentiated human gastric adenocarcinoma cell line, while exhibiting no impact on MKN28 cells, a moderately differentiated counterpart, with MKN45 cells displaying a higher growth rate [4]. Additionally, exposures to Furosemide sodium at concentrations of 10 µM, 30 µM, and 100 µM for 45 minutes substantially reduce cation channel activity and intracellular Ca(2+) levels in human erythrocytes from healthy individuals. Conversely, Tert-butylhydroperoxide increases non-selective cation channel activity and intracellular Ca(2+) concentrations, promoting cell membrane scrambling, which is notably mitigated by Furosemide sodium [5].
In vivo Furosemide sodium (intraperitoneal injection; 100 mg/kg; single dose) is administered following kanamycin (KM) (1000 mg/kg) to establish a deaf mouse model in C57BL/6 mice. This regimen leads to the evaluation of hearing loss and cochlear hair cell damage on days 1, 2, and 3 post-injection. Marked deterioration in hearing is observed as early as the next day (Day-1 group), with the morphology of outer hair cells (OHCs) within the apical, middle, and basal turns of the cochlea becoming disorganized by day 3[1].
Synonyms Frusemide Sodium, Lasix
Molecular Weight 352.73
Formula C12H10ClN2NaO5S
CAS No. 41733-55-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 135mg/mL (382.7mM)

TargetMolReferences and Literature

1. C M Gillen, et al. Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family. J Biol Chem. 1996 Jul 5;271(27):16237-44. 2. S A Thompson, et al. Residues in transmembrane domains I and II determine gamma-aminobutyric acid type AA receptor subtype-selective antagonism by Furosemide sodium. Mol Pharmacol. 1999 Jun;55(6):993-9. 3. Shin Hye Kim, et al. Novel Peptide Vaccine GV1001 Rescues Hearing in Kanamycin/Furosemide sodium-Treated Mice. Front Cell Neurosci. 2018 Jan 19;12:3. 4. Atsushi Shiozaki , et al. Furosemide sodium, a blocker of Na+/K+/2Cl- cotransporter, diminishes proliferation of poorly differentiated human gastric cancer cells by affecting G0/G1 state. J Physiol Sci. 2006 Dec;56(6):401-6. 5. Yuliya V Kucherenko, et al.Inhibitory effect of Furosemide sodium on non-selective voltage-independent cation channels in human erythrocytes.Cell Physiol Biochem. 2012;30(4):863-75.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Clinical Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Cancer Compound Library FDA-Approved Drug Library Drug Repurposing Compound Library Approved Drug Library Inhibitor Library

Related Products

Related compounds with same targets
Azosemide Torsemide

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Furosemide sodium 41733-55-5 Membrane transporter/Ion channel Na-K-Cl cotransporter Frusemide Sodium Lasix inhibitor inhibit

 

TargetMol