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Furosemide sodium

Name: Furosemide sodium
Brand: TargetMol
SKU: T35336
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35336Cas No. 41733-55-5

Alias Lasix, Frusemide Sodium

Furosemide sodium (Frusemide Sodium) is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema.

Furosemide sodium

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Purity: 99.52%

Catalog No. T35336Alias Lasix, Frusemide SodiumCas No. 41733-55-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.52%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Furosemide sodium (Frusemide Sodium) is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema.
Targets&IC50	NKCC:, GABAA receptor:
In vitro	Furosemide sodium, at a concentration of 500 µM administered over 72-96 hours, significantly alters the proliferation rates of MKN45 cells, a poorly differentiated human gastric adenocarcinoma cell line, while exhibiting no impact on MKN28 cells, a moderately differentiated counterpart, with MKN45 cells displaying a higher growth rate [4]. Additionally, exposures to Furosemide sodium at concentrations of 10 µM, 30 µM, and 100 µM for 45 minutes substantially reduce cation channel activity and intracellular Ca(2+) levels in human erythrocytes from healthy individuals. Conversely, Tert-butylhydroperoxide increases non-selective cation channel activity and intracellular Ca(2+) concentrations, promoting cell membrane scrambling, which is notably mitigated by Furosemide sodium [5].
In vivo	Furosemide sodium (intraperitoneal injection; 100 mg/kg; single dose) is administered following kanamycin (KM) (1000 mg/kg) to establish a deaf mouse model in C57BL/6 mice. This regimen leads to the evaluation of hearing loss and cochlear hair cell damage on days 1, 2, and 3 post-injection. Marked deterioration in hearing is observed as early as the next day (Day-1 group), with the morphology of outer hair cells (OHCs) within the apical, middle, and basal turns of the cochlea becoming disorganized by day 3[1].
Synonyms	Lasix, Frusemide Sodium

Chemical Properties

Molecular Weight	352.73
Formula	C₁₂H₁₀ClN₂NaO₅S
Cas No.	41733-55-5
Smiles	O=C([O-])C1=CC(S(=O)(N)=O)=C(Cl)C=C1NCC2=CC=CO2.[Na+]

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (708.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8350 mL	14.1751 mL	28.3503 mL	141.7515 mL
5 mM	0.5670 mL	2.8350 mL	5.6701 mL	28.3503 mL
10 mM	0.2835 mL	1.4175 mL	2.8350 mL	14.1751 mL
20 mM	0.1418 mL	0.7088 mL	1.4175 mL	7.0876 mL
50 mM	0.0567 mL	0.2835 mL	0.5670 mL	2.8350 mL
100 mM	0.0284 mL	0.1418 mL	0.2835 mL	1.4175 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc