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Anti-Serpin B3 Antibody (2B774)

😃Good
Catalog No. TMAY-02539
Alias T4-A, serpin peptidase inhibitor, clade B (ovalbumin), member 3, SCCA-PD, SCCA-1, SCCA1, SCC, HsT1196

Anti-Serpin B3 Antibody (2B774) is a Mouse antibody targeting Serpin B3. Anti-Serpin B3 Antibody (2B774) can be used in WB,ELISA.

Anti-Serpin B3 Antibody (2B774)

Anti-Serpin B3 Antibody (2B774)

😃Good
Catalog No. TMAY-02539Alias T4-A, serpin peptidase inhibitor, clade B (ovalbumin), member 3, SCCA-PD, SCCA-1, SCCA1, SCC, HsT1196
Anti-Serpin B3 Antibody (2B774) is a Mouse antibody targeting Serpin B3. Anti-Serpin B3 Antibody (2B774) can be used in WB,ELISA.
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100 μL$198 7-10 days
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Product Introduction

Bioactivity
Description
Anti-Serpin B3 Antibody (2B774) is a Mouse antibody targeting Serpin B3. Anti-Serpin B3 Antibody (2B774) can be used in WB,ELISA.
AliasT4-A, serpin peptidase inhibitor, clade B (ovalbumin), member 3, SCCA-PD, SCCA-1, SCCA1, SCC, HsT1196
Ig Type
Monoclonal Mouse IgG2a
Clone
2B774
Reactivity
Human
Verified Activity
Anti-SerpinB3 mouse monoclonal antibody at 1:500 dilution.

-Lane A: A431 Whole Cell lysate.

-Lysates/proteins at 30 μg per lane.

-Secondary

-Goat Anti-Mouse IgG (H+L)/HRP at 1/10000 dilution.

-Developed using the ECL technique.

-Performed under reducing conditions.

-Predicted band size:45 kDa.

-Observed band size:45 kDa(We are unsure as to the identity of these extra bands.)
Application
WB,ELISA
Recommended Dose
WB: 1:500-1:2000; ELISA: 1:1000-1:2000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SerpinB3 (rh SerpinB3; TMPY-02712; AAB20405.1; Asn2-Pro390). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundSERPINB3, also known as SCCA-1, belongs to the serpin family. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. SERPINB3 is expressed in some hepatocellular carcinoma (at protein level). Its expression is closely related to cellular differentiation in both normal and malignant squamous cells. It seems to also be secreted in plasma by cancerous cells but at a low level. SERPINB3 significantly attenuates apoptosis by contrasting cytochrome c release from the mitochondria and by antichemotactic effect for NK cells. It may act as a protease inhibitor to modulate the host immune response against tumor cells and may be involved in the malignant behavior of squamous cell carcinoma cells.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human SerpinB3 Protein (TMPY-02712)
Antigen Species
Human
Biology Area
Serine Proteases and Regulators
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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