TGS1 Protein, Human, Recombinant (His & SUMO)

Name: TGS1 Protein, Human, Recombinant (His & SUMO)
Brand: TargetMol
SKU: TMPH-02246
Rating: 4.5 (1 reviews)

(Synonyms: Trimethylguanosine synthase, TGS1, PRIP-interacting protein with methyltransferase motif (PIMT;PIPMT), PIMT, Nuclear receptor coactivator 6-interacting protein, NCOA6IP, Hepatocellular carcinoma-associated antigen 137, HCA137, CLL-associated antigen KW-2, Cap-specific guanine-N(2) methyltransferase) Copy Product Info

Synonyms: Trimethylguanosine synthase, TGS1, PRIP-interacting protein with methyltransferase motif (PIMT;PIPMT), PIMT, Nuclear receptor coactivator 6-interacting protein, NCOA6IP, Hepatocellular carcinoma-associated antigen 137, HCA137, CLL-associated antigen KW-2, Cap-specific guanine-N(2) methyltransferase

Catalog No. TMPH-02246 Copy Product Info

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.

TGS1 Protein, Human, Recombinant (His & SUMO)

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Pack Size	Price	USA Stock	Global Stock
5 μg	$75	20 days	20 days
10 μg	$119	20 days	20 days
20 μg	$198	20 days	20 days
50 μg	$297	20 days	20 days
100 μg	$427	20 days	20 days
200 μg	$658	20 days	20 days
500 μg	$1,170	20 days	20 days
1 mg	$1,830	20 days	20 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Species	Human
Expression System	E. coli
Tag	N-6xHis-SUMO
Accession Number	Q96RS0
Amino Acid	MRVIAIDIDPVKIALARNNAEVYGIADKIEFICGDFLLLASFLKADVVFLSPPWGGPDYATAETFDIRTMMSPDGFEIFRLSKKITNNIVYFLPRNADIDQVASLAGPGGQVEIEQNFLNNKLKTITAYFGDLIRRPASET
Construction	713-853 aa
Protein Purity	> 90% as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Tris-based buffer, 50% glycerol
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Synonyms	Trimethylguanosine synthase, TGS1, PRIP-interacting protein with methyltransferase motif (PIMT;PIPMT), PIMT, Nuclear receptor coactivator 6-interacting protein, NCOA6IP, Hepatocellular carcinoma-associated antigen 137, HCA137, CLL-associated antigen KW-2, Cap-specific guanine-N(2) methyltransferase
Research Background

Chemical Properties

Molecular Weight

31.6 kDa (predicted)

Storage & Solubility Information

Storage

Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months

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Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TGS 1PIPMTHCA 137

Related Tags: TGS1 Protein, Human, Recombinant (His & SUMO) chemical structure | TGS1 Protein, Human, Recombinant (His & SUMO) molecular weight