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Anti-LIFR Antibody (7Q32)
😃Good
Catalog No. TMAY-01040
Alias leukemia inhibitory factor receptor α, leukemia inhibitory factor receptor alpha
Anti-LIFR Antibody (7Q32) is a Rabbit antibody targeting LIFR. Anti-LIFR Antibody (7Q32) can be used in IHC-P.
Anti-LIFR Antibody (7Q32)
Anti-LIFR Antibody (7Q32)
😃Good
Catalog No. TMAY-01040Alias leukemia inhibitory factor receptor α, leukemia inhibitory factor receptor alpha
Anti-LIFR Antibody (7Q32) is a Rabbit antibody targeting LIFR. Anti-LIFR Antibody (7Q32) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: IHC-P Reactivity: Human |
| Alias | leukemia inhibitory factor receptor α, leukemia inhibitory factor receptor alpha |
| Ig Type | Rabbit IgG |
| Clone | 7Q32 |
| Reactivity | Human |
| Verified Activity | Immunochemical staining of human LIFR in human placenta with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to trophoblast. |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human LIFR / CD118 (rh LIFR; TMPY-00991; NP_001121143.1; Met 1-Ser 833). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus affects the differentiation, proliferation, and survival of a wide variety of cells in the adult and the embryo. Besides LIF, LIFR can also bind to and activate CNTF (ciliary neurotrophic factor) and CLC (Cardiotrophin Like Cytokine). Evidence showed that in the retina, LIFR activating LIF, CT-1, and Cardiotrophin Like Cytokine (CLC) are strongly upregulated in response to preconditioning with bright cyclic light leading to robust activation of signal transducer and activator of transcription-3 (STAT3) in a time-dependent manner. Further, blocking LIFR activation during preconditioning using a LIFR antagonist (LIF05) attenuated the induced STAT3 activation and also resulted in reduced preconditioning-induced protection of the retinal photoreceptors. These data demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress. LIFR was newly found to be a suppressor of hepatocellular carcinoma (HCC), one of the world's top five causes of cancer-related deaths. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human LIFR protein (TMPY-00991) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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