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Anti-IKBKB Monoclonal Antibody (6V122)
(Synonyms: IKBKB) Copy Product Info
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Synonyms: IKBKB
Catalog No. TMAT-0524 Copy Product Info
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Anti-IKBKB Monoclonal Antibody (6V122) is a Mouse antibody targeting IKBKB. Anti-IKBKB Monoclonal Antibody (6V122) can be used in IHC.
Anti-IKBKB Monoclonal Antibody
(6V122)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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| Description | Anti-IKBKB Monoclonal Antibody (6V122) is a Mouse antibody targeting IKBKB. Anti-IKBKB Monoclonal Antibody (6V122) can be used in IHC. |
| Synonyms | IKBKB |
| Ig Type | IgG1 |
| Clone | 6V122 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | Ascitic fluid containing 0.03% sodium azide |
| Concentration | 1 mg/ml |
| Research Background | IKBKB(Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, also called IKK2/IKKB), is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of IKBKB expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | IKBKB |
| Gene ID | |
| Protein Name | Inhibitor of nuclear factor kappa-B kinase subunit beta |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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