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SJ1008030 formic

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Catalog No. T77944

SJ1008030 (compound 8) formic is a selective JAK2 degrader from the PROTAC class, exhibiting efficacy in inhibiting MHH-CALL-4 leukemia cell growth with an IC50 of 5.4 nM, and is potentially applicable for leukemia research [1].

SJ1008030 formic
Other Forms of SJ1008030 formic:

SJ1008030 formic

😃Good
Catalog No. T77944
SJ1008030 (compound 8) formic is a selective JAK2 degrader from the PROTAC class, exhibiting efficacy in inhibiting MHH-CALL-4 leukemia cell growth with an IC50 of 5.4 nM, and is potentially applicable for leukemia research [1].
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Product Introduction

Bioactivity
Description
SJ1008030 (compound 8) formic is a selective JAK2 degrader from the PROTAC class, exhibiting efficacy in inhibiting MHH-CALL-4 leukemia cell growth with an IC50 of 5.4 nM, and is potentially applicable for leukemia research [1].
In vitro
SJ1008030 (compound 8) demonstrated activity in the CRLF2r cell line (MHH-CALL-4), with an IC50 of 5.4 nM after 72 hours (formic) [1]. SJ1008030 treatment at concentrations ranging from 0-4.3 μM for 72 hours (formic) led to dose-dependent degradation of JAK, GSPT1, and IKZF1 proteins in MHH-CALL-4 cells [1]. Additionally, at concentrations of 0-10 μM over 24 hours (formic), SJ1008030 induced dose-dependent degradation of JAK2 and GSPT1 proteins in xenografted bone marrow cells (SJBALL021415), indicating inhibition of the JAK-STAT signaling pathway [1].
Chemical Properties
Molecular Weight919.96
FormulaC43H45N13O9S
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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