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SJ1008030 formic

Catalog No. T77944

SJ1008030 (compound 8) formic is a selective JAK2 degrader within the PROTAC class, demonstrating efficacy in inhibiting MHH-CALL-4 leukemia cell growth with an IC50 value of 5.4 nM. It is potentially applicable for leukemia research [1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

SJ1008030 formic, CAS N/A

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

SJ1008030 (compound 8) demonstrated activity in the CRLF2r cell line (MHH-CALL-4), with an IC50 of 5.4 nM after 72 hours (formic) [1]. SJ1008030 treatment at concentrations ranging from 0-4.3 μM for 72 hours (formic) led to dose-dependent degradation of JAK, GSPT1, and IKZF1 proteins in MHH-CALL-4 cells [1]. Additionally, at concentrations of 0-10 μM over 24 hours (formic), SJ1008030 induced dose-dependent degradation of JAK2 and GSPT1 proteins in xenografted bone marrow cells (SJBALL021415), indicating inhibition of the JAK-STAT signaling pathway [1].

Molecular Weight	919.96
Formula	C43H45N13O9S

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Related Products

Related compounds with same targets

Tri-GalNAc-DBCO CCT367766 formic PhosTAC7 MS9449 BT-PROTAC PROTAC SOS1 degrader-4 RSS0680 PROTAC Her3 Degrader-8

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SJ1008030 formic PROTAC PROTACs inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.