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Avanafil

Name: Avanafil
Brand: TargetMol
SKU: T2334
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2334Cas No. 330784-47-9

Alias TA1790

Avanafil (TA1790) is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.

Avanafil

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Purity: 99.03%

Catalog No. T2334Alias TA1790Cas No. 330784-47-9

Avanafil (TA1790) is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$45	In Stock	-
500 mg	$98	Inquiry	Inquiry
1 g	$163	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.03%

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Avanafil (TA1790) is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.
Targets&IC50	PDE1:53000 nM, PDE7:27000 nM, PDE6:630 nM, PDE10:6200 nM, PDE2:51000 nM, PDE4:5700 nM, PDE5:1 nM
In vitro	In the corpus cavernosum of rats with Type 2 Diabetes Mellitus (T2DM), the injection of Avanafil (1 μM) has been demonstrated to enhance erectile function.
Synonyms	TA1790

Chemical Properties

Molecular Weight	483.95
Formula	C₂₃H₂₆ClN₇O₃
Cas No.	330784-47-9
Smiles	C(O)[C@H]1N(C=2N=C(NCC3=CC(Cl)=C(OC)C=C3)C(C(NCC=4N=CC=CN4)=O)=CN2)CCC1
Relative Density.	1.372g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 90 mg/mL (185.97 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0663 mL	10.3316 mL	20.6633 mL	103.3165 mL
5 mM	0.4133 mL	2.0663 mL	4.1327 mL	20.6633 mL
10 mM	0.2066 mL	1.0332 mL	2.0663 mL	10.3316 mL
20 mM	0.1033 mL	0.5166 mL	1.0332 mL	5.1658 mL
50 mM	0.0413 mL	0.2066 mL	0.4133 mL	2.0663 mL
100 mM	0.0207 mL	0.1033 mL	0.2066 mL	1.0332 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc