Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) that primarily acts as a sigma (σ) receptor agonist, exhibiting potent interaction with sigma recognition sites (K i value of 50 nM). It can be employed in the research of generalized anxiety disorder (GAD) [1] [2].
Description | Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) that primarily acts as a sigma (σ) receptor agonist, exhibiting potent interaction with sigma recognition sites (K i value of 50 nM). It can be employed in the research of generalized anxiety disorder (GAD) [1] [2]. |
In vitro | Opipramol effectively engages with sigma recognition sites, exhibiting a K i value of 50 nM [1]. Additionally, it inhibits the uptake of [3H] DA in crude synaptosomal preparations, demonstrating an IC 50 value of 5.5 μM [1]. |
In vivo | Opipramol (i.p.; 5-50 mg/kg) effectively enhances dopamine release in vivo [2], utilizing male Sprague-Dawley rats (150-180 g) as the animal model [2]. Administered through intraperitoneal injections at dosages ranging from 5-50 mg/kg, it notably increases DOPAC and HVA levels in the rat's striatum, without affecting the baseline DA levels. This compound significantly boosts dopamine metabolism within the striatum, olfactory tubercle, and pyriform cortex. Additionally, it elevates plasma prolactin levels, but only at the maximum tested dosage of 50 mg/kg. |
Molecular Weight | 363.5 |
Formula | C23H29N3O |
CAS No. | 315-72-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Opipramol 315-72-0 inhibitor inhibit