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Opipramol

Name: Opipramol
Brand: TargetMol
SKU: T61376
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T61376Cas No. 315-72-0

Alias G-33040, G33040, Ensidon

Opipramol (Ensidon) is a compound with antidepressant activity that attenuates cocaine-seeking behavior in a rat model of self-administration.Opipramol is a sigma (σ) receptor agonist with anxiolytic activity and may be used in the study of neurological disorders.

Opipramol

🥰Excellent

Purity: 99.98%

Catalog No. T61376Alias G-33040, G33040, EnsidonCas No. 315-72-0

Pack Size	Price	Availability
5 mg	$40	In Stock
10 mg	$60	In Stock
25 mg	$123	In Stock
50 mg	$198	In Stock
100 mg	$297	In Stock
200 mg	$455	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.98%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Opipramol (Ensidon) is a compound with antidepressant activity that attenuates cocaine-seeking behavior in a rat model of self-administration.Opipramol is a sigma (σ) receptor agonist with anxiolytic activity and may be used in the study of neurological disorders.
Targets&IC50	sigma recognition site:50 nM (Ki), [3H]-dopamine:5.5 μ
In vitro	Opipramol potently binds to the sigma recognition site with a Ki value of 50 nM. Opipramol also inhibits the uptake of [3H] dopamine in crude synaptic preparations with an IC50 value of 5.5 μM. [1]
In vivo	Opipramol has been shown to significantly increase dopamine release in vivo by intraperitoneal injection (dose range 5-50 mg/kg). [2]
Synonyms	G-33040, G33040, Ensidon

Chemical Properties

Molecular Weight	363.5
Formula	C₂₃H₂₉N₃O
Cas No.	315-72-0
Smiles	OCCN1CCN(CC1)CCCN2C=3C=CC=CC3C=CC=4C=CC=CC42
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (220.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.08 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7510 mL	13.7552 mL	27.5103 mL	137.5516 mL
5 mM	0.5502 mL	2.7510 mL	5.5021 mL	27.5103 mL
10 mM	0.2751 mL	1.3755 mL	2.7510 mL	13.7552 mL
20 mM	0.1376 mL	0.6878 mL	1.3755 mL	6.8776 mL
50 mM	0.0550 mL	0.2751 mL	0.5502 mL	2.7510 mL
100 mM	0.0275 mL	0.1376 mL	0.2751 mL	1.3755 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc