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Rezivertinib

Name: Rezivertinib
Brand: TargetMol
SKU: T36644
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36644Cas No. 1835667-12-3

Alias BPI-7711, BPI7711

Rezivertinib (BPI-7711) is an orally available, selective and potent inhibitor of tyrosine kinase (EGFR) with antitumor activity for central nervous system disorders.

Rezivertinib

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Purity: 99.98%

Catalog No. T36644Alias BPI-7711, BPI7711Cas No. 1835667-12-3

Rezivertinib (BPI-7711) is an orally available, selective and potent inhibitor of tyrosine kinase (EGFR) with antitumor activity for central nervous system disorders.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$58	In Stock	In Stock
5 mg	$139	In Stock	In Stock
10 mg	$196	In Stock	In Stock
25 mg	$363	In Stock	In Stock
50 mg	$518	In Stock	In Stock
100 mg	$745	-	In Stock
200 mg	$987	-	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Appearance:Solid

Color:White to Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Rezivertinib (BPI-7711) is an orally available, selective and potent inhibitor of tyrosine kinase (EGFR) with antitumor activity for central nervous system disorders.
Targets&IC50	NCI-H1975 cells:22 nM (GI50), PC9 cells:13.3 nM (GI50), A431 cells:>1000 nM (GI50), HCC827 cells:6.8 nM (GI50)
In vitro	Rezivertinib selectively inhibits cellular proliferation of EGFR mutations in cell lines: PC9 (GI50=13.3 nM), HCC827 (GI50=6.8 nM), NCI-H1975 (GI50=22 nM) and A431 (GI50>1000 nM). [1]
In vivo	Rezivertinib administered orally for 14 days at 6.25-25 mg/kg/day demonstrated significant tumor regression. In addition, Rezivertinib administered orally at 50 mg/kg/day also showed anti-tumor effects, significantly improving the mean overall survival of the animals, which was prolonged from 13 to 28 days, a 115% improvement. [2]
Synonyms	BPI-7711, BPI7711

Chemical Properties

Molecular Weight	486.57
Formula	C₂₇H₃₀N₆O₃
Cas No.	1835667-12-3
Smiles	O=C(C=C)NC1=CC(NC=2N=CC=C(N2)C3=CN(C=4C=CC=CC34)C)=C(OC)C=C1OCCN(C)C

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (205.52 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0552 mL	10.2760 mL	20.5520 mL	102.7601 mL
5 mM	0.4110 mL	2.0552 mL	4.1104 mL	20.5520 mL
10 mM	0.2055 mL	1.0276 mL	2.0552 mL	10.2760 mL
20 mM	0.1028 mL	0.5138 mL	1.0276 mL	5.1380 mL
50 mM	0.0411 mL	0.2055 mL	0.4110 mL	2.0552 mL
100 mM	0.0206 mL	0.1028 mL	0.2055 mL	1.0276 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc