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Rezivertinib

Name: Rezivertinib
Brand: TargetMol
SKU: T36644
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36644Cas No. 1835667-12-3

Alias BPI-7711, BPI7711

Rezivertinib (BPI-7711) is an orally available, selective and potent inhibitor of tyrosine kinase (EGFR) with antitumor activity for central nervous system disorders.

Rezivertinib

🥰Excellent

Purity: 99.89%

Catalog No. T36644Alias BPI-7711, BPI7711Cas No. 1835667-12-3

Rezivertinib (BPI-7711) is an orally available, selective and potent inhibitor of tyrosine kinase (EGFR) with antitumor activity for central nervous system disorders.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$58	In Stock	In Stock
5 mg	$139	In Stock	In Stock
10 mg	$196	In Stock	In Stock
25 mg	$363	In Stock	In Stock
50 mg	$518	In Stock	In Stock
100 mg	$745	-	In Stock
200 mg	$987	-	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Rezivertinib (BPI-7711) is an orally available, selective and potent inhibitor of tyrosine kinase (EGFR) with antitumor activity for central nervous system disorders.
Targets&IC50	PC9 cells:13.3 nM (GI50), HCC827 cells:6.8 nM (GI50), NCI-H1975 cells:22 nM (GI50), A431 cells:>1000 nM (GI50)
In vitro	Rezivertinib selectively inhibits cellular proliferation of EGFR mutations in cell lines: PC9 (GI50=13.3 nM), HCC827 (GI50=6.8 nM), NCI-H1975 (GI50=22 nM) and A431 (GI50>1000 nM). [1]
In vivo	Rezivertinib administered orally for 14 days at 6.25-25 mg/kg/day demonstrated significant tumor regression. In addition, Rezivertinib administered orally at 50 mg/kg/day also showed anti-tumor effects, significantly improving the mean overall survival of the animals, which was prolonged from 13 to 28 days, a 115% improvement. [2]
Synonyms	BPI-7711, BPI7711

Chemical Properties

Molecular Weight	486.57
Formula	C₂₇H₃₀N₆O₃
Cas No.	1835667-12-3
Smiles	O=C(C=C)NC1=CC(NC=2N=CC=C(N2)C3=CN(C=4C=CC=CC34)C)=C(OC)C=C1OCCN(C)C

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (205.52 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0552 mL	10.2760 mL	20.5520 mL	102.7601 mL
5 mM	0.4110 mL	2.0552 mL	4.1104 mL	20.5520 mL
10 mM	0.2055 mL	1.0276 mL	2.0552 mL	10.2760 mL
20 mM	0.1028 mL	0.5138 mL	1.0276 mL	5.1380 mL
50 mM	0.0411 mL	0.2055 mL	0.4110 mL	2.0552 mL
100 mM	0.0206 mL	0.1028 mL	0.2055 mL	1.0276 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc