Thrombopoietin Protein, Human, Recombinant (hFc)

Catalog No. TMPY-04201 Copy Product Info

Thrombopoietin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45 kDa and the accession number is P40225-1.

Thrombopoietin Protein, Human, Recombinant (hFc)

Catalog No. TMPY-04201

Copy Product Info

Thrombopoietin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45 kDa and the accession number is P40225-1.

Pack Size	Price	USA Stock	Global Stock
5 μg	$63	7-10 days	7-10 days
10 μg	$98	7-10 days	7-10 days
20 μg	$163	7-10 days	7-10 days
50 μg	$323	7-10 days	7-10 days
100 μg	$625	7-10 days	7-10 days
200 μg	$939	7-10 days	7-10 days
500 μg	$1,970	7-10 days	7-10 days
1 mg	$3,970	7-10 days	7-10 days

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In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Information

Biological Activity	Recombinant Human TPO/Thrombopoietin Protein, hFc Tag (Cat#TMPY-04201) captured on Protein A chip can bind Recombinant Human TPO-R Protein, His Tag (Cat#TMPY-06797) with an affinity constant of 12.3 nM as determined in an SPR assay (Biacore 8K) (Routinely tested).
Description	Thrombopoietin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45 kDa and the accession number is P40225-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	P40225-1
Synonyms	TPO,thrombopoietin,THCYT1,MPLLG,ML,MKCSF,MGDF
Construction	A DNA sequence encoding the human THPO (NP_000451.1) (Met1-Leu192) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Ser 22
Protein Purity	> 70 % as determined by SDS-PAGE.
Molecular Weight	45 kDa (predicted)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Research Background	Thrombopoietin (TPO or THPO), also known as myeloproliferative leukemia virus ligand (c-Mpl), is a hematopoietic growth factor belonging to the EPO/TPO family. The thrombopoietin protein is produced mainly by the liver and the kidney that regulates the production of platelets by the bone marrow. Thrombopoietin protein stimulates both proliferation of progenitor megakaryocytes and their maturation to platelet-producing megakaryocytes, and also accelerates the recovery of platelets. Thrombopoietin protein is involved in cardiovascular disease as it regulates megakaryocyte development and enhances platelet adhesion/aggregation. It has been identified that surface c-MPL, the receptor for thrombopoietin protein, binds to the ligand and mediates the action.