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JNJ-5207787
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Catalog No. T15620Cas No. 683746-68-1
Alias JNJ5207787, JNJ 5207787
JNJ-5207787 is a blood–brain barrier penetrant neuropeptide Y Y2 receptor antagonist that demonstrates greater than 100-fold selectivity over Y1, Y4, and Y5 receptor subtypes, JNJ-5207787 potently suppresses peptide YY binding at both human and rat Y2 receptors, supporting the use of JNJ-5207787 in central nervous system research focused on neuropeptide signaling.
JNJ-5207787
😃Good
Catalog No. T15620Alias JNJ5207787, JNJ 5207787Cas No. 683746-68-1
JNJ-5207787 is a blood–brain barrier penetrant neuropeptide Y Y2 receptor antagonist that demonstrates greater than 100-fold selectivity over Y1, Y4, and Y5 receptor subtypes, JNJ-5207787 potently suppresses peptide YY binding at both human and rat Y2 receptors, supporting the use of JNJ-5207787 in central nervous system research focused on neuropeptide signaling.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $139 | - | In Stock | |
| 5 mg | $347 | - | In Stock | |
| 10 mg | $515 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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| Description | JNJ-5207787 is a blood–brain barrier penetrant neuropeptide Y Y2 receptor antagonist that demonstrates greater than 100-fold selectivity over Y1, Y4, and Y5 receptor subtypes, JNJ-5207787 potently suppresses peptide YY binding at both human and rat Y2 receptors, supporting the use of JNJ-5207787 in central nervous system research focused on neuropeptide signaling. |
| Targets&IC50 | Y2 receptor (human):7.0 (pic50), Y2 receptor (rat):7.1 (pic50) |
| In vitro | JNJ-5207787 (10 μM; 15 min) suppresses [125I]PYY labeling in the lateral septum, cerebellum, ventral tegmental area, substantia nigra, hippocampus, septum, amygdala, and hypothalamus. JNJ-5207787 (0.01, 0.1, 1, 10 μM) has antagonistic properties and suppresses the PYY-stimulated [35S]GTPγS binding to basal level with a p IC50 corr of 7.20 [1]. |
| In vivo | JNJ-5207787 (i.p.; 30 mg/kg) penetrates the brain (Cmax=1351 ng/ml at 30 min) and occupies Y2 receptor binding sites[1]. |
| Synonyms | JNJ5207787, JNJ 5207787 |
| Molecular Weight | 510.67 |
| Formula | C32H38N4O2 |
| Cas No. | 683746-68-1 |
| Smiles | N(C(/C=C/C1=CC(C#N)=CC=C1)=O)(C=2C=C3C(=CC2)CCN3C(C)=O)C4CCN(CCC5CCCC5)CC4 |
| Relative Density. | 1.22 g/cm3 |
| Color | Yellow |
| Appearance | Solid |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (7.83 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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