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Anti-Phospho-PDCD4 (Ser67) Polyclonal Antibody 2
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Catalog No. TMAB-11123
Anti-Phospho-PDCD4 (Ser67) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-PDCD4 (Ser67). Anti-Phospho-PDCD4 (Ser67) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,ICC/IF,IF,FCM.
Anti-Phospho-PDCD4 (Ser67) Polyclonal Antibody 2
Anti-Phospho-PDCD4 (Ser67) Polyclonal Antibody 2
😃Good
Catalog No. TMAB-11123
Anti-Phospho-PDCD4 (Ser67) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-PDCD4 (Ser67). Anti-Phospho-PDCD4 (Ser67) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,ICC/IF,IF,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-PDCD4 (Ser67) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-PDCD4 (Ser67). Anti-Phospho-PDCD4 (Ser67) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,ICC/IF,IF,FCM. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; FCM: 2μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Cytoplasm. Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum. |
| Tissue Specificity | Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010] |
| Immunogen | KLH conjugated synthesised phosphopeptide: human PDCD4 around the phosphorylation site of Ser67 |
| Antigen Species | Human |
| Gene Name | PDCD4 |
| Gene ID | |
| Protein Name | Programmed cell death protein 4 |
| Uniprot ID | |
| Function | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA. |
| Molecular Weight | Theoretical: 51 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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