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Anti-Siglec-2/CD22 Antibody (NCI m971)
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Catalog No. T9901A-1474
Alias NCI m971
Anti-Siglec-2/CD22 Antibody (NCI m971) is a highly specialized fully human monoclonal antibody fragment target the Siglec-2 surface antigen with exceptional binding affinity, internalization of the antibody-receptor complex across various preclinical experimental models of B-cell malignancies to evaluate cytotoxic efficacy.
Anti-Siglec-2/CD22 Antibody (NCI m971)
Anti-Siglec-2/CD22 Antibody (NCI m971)
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Catalog No. T9901A-1474Alias NCI m971
Anti-Siglec-2/CD22 Antibody (NCI m971) is a highly specialized fully human monoclonal antibody fragment target the Siglec-2 surface antigen with exceptional binding affinity, internalization of the antibody-receptor complex across various preclinical experimental models of B-cell malignancies to evaluate cytotoxic efficacy.
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| Description | Anti-Siglec-2/CD22 Antibody (NCI m971) is a highly specialized fully human monoclonal antibody fragment target the Siglec-2 surface antigen with exceptional binding affinity, internalization of the antibody-receptor complex across various preclinical experimental models of B-cell malignancies to evaluate cytotoxic efficacy. |
| Targets&IC50 | CD22:~2-10 nM |
| In vitro | In cytotoxicity assays using CD22-expressing leukemia cell lines, CAR-T cells incorporating Anti-Siglec-2/CD22 Antibody (NCI m971) demonstrated potent lytic activity and cytokine production [1]. |
| In vivo | In human leukemia xenograft models, systemic administration of CAR-T cells incorporating Anti-Siglec-2/CD22 Antibody (NCI m971) resulted in complete tumor eradication and prolonged survival [1]. |
| Synonyms | NCI m971 |
| Clone | NCI m971 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | Siglec-2/CD22 |
| Isotype | IgG1 |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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