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Anti-CEACAM5 Antibody (2J586)
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Catalog No. TMAY-01608
Alias CEA, CD66e, carcinoembryonic antigen-related cell adhesion molecule 5
Anti-CEACAM5 Antibody (2J586) is a Rabbit antibody targeting CEACAM5. Anti-CEACAM5 Antibody (2J586) can be used in IHC-P.
Anti-CEACAM5 Antibody (2J586)
Anti-CEACAM5 Antibody (2J586)
😃Good
Catalog No. TMAY-01608Alias CEA, CD66e, carcinoembryonic antigen-related cell adhesion molecule 5
Anti-CEACAM5 Antibody (2J586) is a Rabbit antibody targeting CEACAM5. Anti-CEACAM5 Antibody (2J586) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-CEACAM5 Antibody (2J586) is a Rabbit antibody targeting CEACAM5. Anti-CEACAM5 Antibody (2J586) can be used in IHC-P. |
| Alias | CEA, CD66e, carcinoembryonic antigen-related cell adhesion molecule 5 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 2J586 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human CEACAM5 in human rectal cancer with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to intestinal gland. 2. Immunochemical staining of human CEACAM5 in human colon carcinoma with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to intestinal gland. |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human CEACAM5 / CD66e (rh CEACAM5 / CD66e; TMPY-01647; NP_004354.2; Met1-Ala685). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | CEACAM5, also known as CEA or CD66e, belongs to the large CEACAM subfamily of the immunoglobulin superfamily. CEACAM5 is expressed primarily by epithelial cells, and is synthesized as a glycoprotein with an MW of 180 kDa comprising 60% carbohydrate. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domains and a GPI anchor, and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with adhesion and invasion. CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation. In addition, CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.Coli, and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human CEACAM5 / CD66e protein (TMPY-01647) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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