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Anti-Phospho-PIK3R1 (Tyr368) Polyclonal Antibody
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Catalog No. TMAB-11138
Anti-Phospho-PIK3R1 (Tyr368) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PIK3R1 (Tyr368). Anti-Phospho-PIK3R1 (Tyr368) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-PIK3R1 (Tyr368) Polyclonal Antibody
Anti-Phospho-PIK3R1 (Tyr368) Polyclonal Antibody
😃Good
Catalog No. TMAB-11138
Anti-Phospho-PIK3R1 (Tyr368) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PIK3R1 (Tyr368). Anti-Phospho-PIK3R1 (Tyr368) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-PIK3R1 (Tyr368) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PIK3R1 (Tyr368). Anti-Phospho-PIK3R1 (Tyr368) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Dog,Pig,Cow,Horse) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasmic. |
| Tissue Specificity | Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level). |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human PIK3R1 around the phosphorylation site of Tyr368 |
| Antigen Species | Human |
| Gene Name | PIK3R1 |
| Gene ID | |
| Protein Name | Phosphatidylinositol 3-kinase regulatory subunit alpha |
| Uniprot ID | |
| Function | Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. |
| Molecular Weight | Theoretical: 84 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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