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ESBA-105
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Catalog No. T9901A-1362 Copy Product Info
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ESBA-105 represents a highly stable, humanized single-chain Fv (scFv) antibody fragment specifically engineered to target and neutralize human tumor necrosis factor-alpha (TNF-α) with exceptional binding affinity. It effectively facilitates the measurable blockade of TNF-mediated pro-inflammatory signaling and apoptosis across various preclinical experimental models to evaluate the optimization of tissue penetration and pharmacokinetic stability during strictly monitored laboratory observation periods and functional neutralization assays.
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| Description | ESBA-105 represents a highly stable, humanized single-chain Fv (scFv) antibody fragment specifically engineered to target and neutralize human tumor necrosis factor-alpha (TNF-α) with exceptional binding affinity. It effectively facilitates the measurable blockade of TNF-mediated pro-inflammatory signaling and apoptosis across various preclinical experimental models to evaluate the optimization of tissue penetration and pharmacokinetic stability during strictly monitored laboratory observation periods and functional neutralization assays. |
| Targets & IC50 | TNF-α:~150 - 200 pM |
| In vitro | In standardized neutralization assays using L929 fibroblast cells, ESBA-105 inhibited TNF-alpha induced cytotoxicity in a dose-dependent manner [1]. |
| In vivo | In rabbit models of ocular delivery, topical administration of ESBA-105 resulted in rapid tissue distribution and reached therapeutic concentrations in the aqueous and vitreous humor [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | TNFSF2/TNFa |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: ESBA-105 chemical structure | ESBA-105 in vivo | ESBA-105 in vitro
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