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Verapamil hydrochloride

Name: Verapamil hydrochloride
Brand: TargetMol
SKU: T1010
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1010Cas No. 152-11-4

Alias Verapamil HCl, Manidon, Calcan hydrochloride, (±)-Verapamil hydrochlorid

Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.

Verapamil hydrochloride

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Purity: 254

Catalog No. T1010Alias Verapamil HCl, Manidon, Calcan hydrochloride, (±)-Verapamil hydrochloridCas No. 152-11-4

Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$41	In Stock	In Stock
1 g	$48	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:254

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.
In vitro	Verapamil exhibits antiarrhythmic properties, reduces myocardial oxygen consumption in rats, and preserves Cx43 protein.
In vivo	Verapamil and Diltiazem essentially inhibit the hydrolase activity of recombinant CES2, with inhibition constants (Ki) of 0.25 ± 0.02 μM and 3.84 ± 0.99 μM, respectively.
Cell Research	Verapamil is dissolved in DMSO and stored, and then diluted with appropriate media before use[1]. Cells (1×105) are treated with 10 nM Bortezomib and/or 70 μM Verapamil for 16 hours and incubated for another 4 hours with Alamar-Blue. Activity of the mitochondrial dehydrogenase results in conversion of the coloring, which is followed by measurement of the absorption using a spectrophotometer[1].
Synonyms	Verapamil HCl, Manidon, Calcan hydrochloride, (±)-Verapamil hydrochlorid

Chemical Properties

Molecular Weight	491.06
Formula	C₂₇H₃₉ClN₂O₄
Cas No.	152-11-4
Smiles	Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
Relative Density.	1.058g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 86.67 mg/mL (176.5 mM), Sonication is recommended.

H2O: 24.6 mg/mL (50.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0364 mL	10.1821 mL	20.3641 mL	101.8206 mL
5 mM	0.4073 mL	2.0364 mL	4.0728 mL	20.3641 mL
10 mM	0.2036 mL	1.0182 mL	2.0364 mL	10.1821 mL
20 mM	0.1018 mL	0.5091 mL	1.0182 mL	5.0910 mL
50 mM	0.0407 mL	0.2036 mL	0.4073 mL	2.0364 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0204 mL	0.1018 mL	0.2036 mL	1.0182 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc