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Dimethindene

Name: Dimethindene
Brand: TargetMol
SKU: T31488
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T31488Cas No. 5636-83-9

Alias Z-2001, Z2001, Z 2001, Dimetindeno, Dimetindene

Dimethindene (Dimetindeno) is a selective antagonist of H1 receptor and blocks K+ current. Dimethindene exhibits antihistamine and anticholinergic effects.

Dimethindene

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Purity: 98.99%

Catalog No. T31488Alias Z-2001, Z2001, Z 2001, Dimetindeno, DimetindeneCas No. 5636-83-9

Dimethindene (Dimetindeno) is a selective antagonist of H1 receptor and blocks K+ current. Dimethindene exhibits antihistamine and anticholinergic effects.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	-	In Stock
5 mg	Preferential	-	In Stock
10 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.99%

Appearance:Oil

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Dimethindene (Dimetindeno) is a selective antagonist of H1 receptor and blocks K+ current. Dimethindene exhibits antihistamine and anticholinergic effects.
In vitro	In follicle-enclosed Xenopus oocytes, Dimethindene (5-500 μM) decreases Cromakalim cromakalim-induced K+ currents (IC50 = 29.5 μM)[1].
In vivo	In C57BL/6 mice with skin wound healing, Dimethindene (0.25 mg; i.p.) impairs cutaneous wound healing and delays skin wound closure[2].
Synonyms	Z-2001, Z2001, Z 2001, Dimetindeno, Dimetindene

Chemical Properties

Molecular Weight	292.42
Formula	C₂₀H₂₄N₂
Cas No.	5636-83-9
Smiles	C(C)(C=1C=2C(CC1CCN(C)C)=CC=CC2)C3=CC=CC=N3
Relative Density.	1.0073 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (188.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4197 mL	17.0987 mL	34.1974 mL	170.9869 mL
5 mM	0.6839 mL	3.4197 mL	6.8395 mL	34.1974 mL
10 mM	0.3420 mL	1.7099 mL	3.4197 mL	17.0987 mL
20 mM	0.1710 mL	0.8549 mL	1.7099 mL	8.5493 mL
50 mM	0.0684 mL	0.3420 mL	0.6839 mL	3.4197 mL
100 mM	0.0342 mL	0.1710 mL	0.3420 mL	1.7099 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc