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Dimethindene

Name: Dimethindene
Brand: TargetMol
SKU: T31488
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T31488Cas No. 5636-83-9

Alias Z-2001, Z2001, Z 2001, Dimetindeno, Dimetindene

Dimethindene (Dimetindeno) is a selective antagonist of H1 receptor and blocks K+ current. Dimethindene exhibits antihistamine and anticholinergic effects.

Dimethindene

🥰Excellent

Purity: 98.99%

Catalog No. T31488Alias Z-2001, Z2001, Z 2001, Dimetindeno, DimetindeneCas No. 5636-83-9

Dimethindene (Dimetindeno) is a selective antagonist of H1 receptor and blocks K+ current. Dimethindene exhibits antihistamine and anticholinergic effects.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	-	In Stock
5 mg	$113	-	In Stock
10 mg	$166	-	In Stock
25 mg	$248	-	In Stock
50 mg	$369	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.99%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Dimethindene (Dimetindeno) is a selective antagonist of H1 receptor and blocks K+ current. Dimethindene exhibits antihistamine and anticholinergic effects.
In vitro	In follicle-enclosed Xenopus oocytes, Dimethindene (5-500 μM) decreases Cromakalim cromakalim-induced K+ currents (IC50 = 29.5 μM)[1].
In vivo	In C57BL/6 mice with skin wound healing, Dimethindene (0.25 mg; i.p.) impairs cutaneous wound healing and delays skin wound closure[2].
Synonyms	Z-2001, Z2001, Z 2001, Dimetindeno, Dimetindene

Chemical Properties

Molecular Weight	292.42
Formula	C₂₀H₂₄N₂
Cas No.	5636-83-9
Smiles	C(C)(C=1C=2C(CC1CCN(C)C)=CC=CC2)C3=CC=CC=N3
Relative Density.	1.0073 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (188.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4197 mL	17.0987 mL	34.1974 mL	170.9869 mL
5 mM	0.6839 mL	3.4197 mL	6.8395 mL	34.1974 mL
10 mM	0.3420 mL	1.7099 mL	3.4197 mL	17.0987 mL
20 mM	0.1710 mL	0.8549 mL	1.7099 mL	8.5493 mL
50 mM	0.0684 mL	0.3420 mL	0.6839 mL	3.4197 mL
100 mM	0.0342 mL	0.1710 mL	0.3420 mL	1.7099 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc