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Anti-Phospho-SIRT1 (Ser47) Antibody (5Z724)
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Catalog No. TMAC-03761
Alias sirtuin 1, SIRT1 (p-Ser47), SIRT1 (p-S47), SIR2L1, p-SIRT1 (Ser47), p-SIRT1 (S47)
Anti-Phospho-SIRT1 (S47) Antibody (5Z724) is a Rabbit antibody targeting Phospho-SIRT1 (S47). Anti-Phospho-SIRT1 (S47) Antibody (5Z724) can be used in WB,ICC,IHC.
Anti-Phospho-SIRT1 (Ser47) Antibody (5Z724)
Anti-Phospho-SIRT1 (Ser47) Antibody (5Z724)
😃Good
Catalog No. TMAC-03761Alias sirtuin 1, SIRT1 (p-Ser47), SIRT1 (p-S47), SIR2L1, p-SIRT1 (Ser47), p-SIRT1 (S47)
Anti-Phospho-SIRT1 (S47) Antibody (5Z724) is a Rabbit antibody targeting Phospho-SIRT1 (S47). Anti-Phospho-SIRT1 (S47) Antibody (5Z724) can be used in WB,ICC,IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $298 | 7-10 days | |
| 100 μL | $496 | 7-10 days |
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| Description | Anti-Phospho-SIRT1 (Ser47) Antibody (5Z724) is a Rabbit antibody targeting Phospho-SIRT1 (Ser47). Anti-Phospho-SIRT1 (Ser47) Antibody (5Z724) can be used in WB,ICC,IHC. |
| Synonyms | sirtuin 1, SIRT1 (p-Ser47), SIRT1 (p-S47), SIR2L1, p-SIRT1 (Ser47), p-SIRT1 (S47) |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | 1. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-SIRT1(phospho S47) antibody. Counter stained with hematoxylin. 2. ICC staining SIRT1(phospho S47) in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 3. ICC staining SIRT1(phospho S47) in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. ICC staining SIRT1(phospho S47) in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| Application | |
| Recommended Dose | WB: 1:1000; IHC: 1:50-200; ICC: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The silent information regulator (SIR2) family of genes are highly-conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. In S. cerevisiae, Sir2p deacetylates histones in an NAD-dependent manner, which regulates silencing at the telomeric, rDNA and silent mating-type loci. Sir2p is the founding member of a large family, designated sirtuins, which contain a conserved catalytic domain. The human homologs, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT1 has the closest homology to the yeast Sir2p and is widely expressed in fetal and adult tissues. SIRT1 is highly expressed in heart, brain and skeletal muscle, with low expression in lung and placenta. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically at Lys 382. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | A synthesized phosphopeptide: human SIRT1 around the phosphorylation site of Ser47 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Theoretical: 82 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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