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MrgprX2 antagonist-1

Name: MrgprX2 antagonist-1
Brand: TargetMol
SKU: T40270
Price: 169 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40270Cas No. 2642162-06-7

MrgprX2 antagonist-1 (compound E23) is a MrgprX2 antagonist applicable to cutaneous inflammation.

MrgprX2 antagonist-1

🥰Excellent

Catalog No. T40270Cas No. 2642162-06-7

MrgprX2 antagonist-1 (compound E23) is a MrgprX2 antagonist applicable to cutaneous inflammation.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$169	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description

MrgprX2 antagonist-1 (compound E23) is a MrgprX2 antagonist applicable to cutaneous inflammation.

In vitro

As a member of the Mas-related gene family, MRGPRX2 is not only expressed in sensory neurons and mast cells, but recent studies have also found its expression in keratinocytes. In terms of tissue distribution, MRGPRX2 mRNA is present in adipose tissue, esophagus, bladder, lung, and other regions, with particularly high expression levels in the skin. Upon activation, MRGPRX2 can induce degranulation in mast cells, subsequently triggering a pseudo-anaphylactic response [2].

Chemical Properties

Molecular Weight	410.36
Formula	C₁₅H₁₅F₅N₄O₂S
Cas No.	2642162-06-7
Smiles	C(C=1SC(NC(N(C[C@H](C(F)(F)F)O)CC)=O)=NN1)C2=CC(F)=CC(F)=C2
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (121.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (6.09 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4369 mL	12.1844 mL	24.3688 mL	121.8442 mL
5 mM	0.4874 mL	2.4369 mL	4.8738 mL	24.3688 mL
10 mM	0.2437 mL	1.2184 mL	2.4369 mL	12.1844 mL
20 mM	0.1218 mL	0.6092 mL	1.2184 mL	6.0922 mL
50 mM	0.0487 mL	0.2437 mL	0.4874 mL	2.4369 mL
100 mM	0.0244 mL	0.1218 mL	0.2437 mL	1.2184 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc