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Vadadustat

Name: Vadadustat
Brand: TargetMol
SKU: T4651
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T4651Cas No. 1000025-07-9

Alias PG-1016548, AKB-6548

Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.

Vadadustat

🥰Excellent

Purity: 99.80%

Catalog No. T4651Alias PG-1016548, AKB-6548Cas No. 1000025-07-9

Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.

Pack Size	Price	Availability
1 mg	$42	In Stock
5 mg	$99	In Stock
10 mg	$157	In Stock
25 mg	$260	In Stock
50 mg	$400	In Stock
1 mL x 10 mM (in DMSO)	$99	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.80%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.
Targets&IC50	PH2:0.029 μM, FIH (factor inhibiting HIF):29 μM
Synonyms	PG-1016548, AKB-6548

Chemical Properties

Molecular Weight	306.7
Formula	C₁₄H₁₁ClN₂O₄
Cas No.	1000025-07-9
Smiles	OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Relative Density.	1.461 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (326.05 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2605 mL	16.3026 mL	32.6052 mL	163.0258 mL
5 mM	0.6521 mL	3.2605 mL	6.5210 mL	32.6052 mL
10 mM	0.3261 mL	1.6303 mL	3.2605 mL	16.3026 mL
20 mM	0.1630 mL	0.8151 mL	1.6303 mL	8.1513 mL
50 mM	0.0652 mL	0.3261 mL	0.6521 mL	3.2605 mL
100 mM	0.0326 mL	0.1630 mL	0.3261 mL	1.6303 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc