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Antibacterial agent 131

Name: Antibacterial agent 131
Brand: TargetMol
SKU: T72309
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72309

Antibacterial agent 131 is a compound with antibacterial properties.

Antibacterial agent 131

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Purity: 99.63%

Catalog No. T72309

Antibacterial agent 131 is a compound with antibacterial properties.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	-	In Stock
5 mg	$103	-	In Stock
10 mg	$167	-	In Stock
25 mg	$279	-	In Stock
50 mg	$397	-	In Stock
100 mg	$538	-	In Stock
200 mg	$691	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.63%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

Antibacterial agent 131 is a compound with antibacterial properties.

In vitro

Antibacterial agent 131 (compound 4m) exhibits antibacterial activity with MIC90 values of 9.81 μg/mL against Escherichia coli ATCC 35218, E. coli ATCC 25922, Staphylococcus aureus ATCC 6538, and methicillin-resistant S. aureus (MRSA), and shows anti-Candida effects with MIC90 values of ≤0.06, 0.24, 1.95, and 1.95 μg/mL against Candida krusei ATCC 6258, Candida parapsilosis ATCC 22019, Candida albicans ATCC 24433, and C. glabrata ATCC 90030, respectively. Additionally, it has low cytotoxicity with an IC50 value of 34.51 μM in NIH/3T3 cells, inhibits DNA gyrase against Escherichia coli at concentrations of 0.06-3.91 μg/mL, and has antifungal activity by blocking ergosterol production.[1]

Chemical Properties

Molecular Weight	444.94
Formula	C₂₄H₁₇ClN₄OS
Smiles	ClC1=NC2=CC=C(OC)C=C2C=C1/C=N/NC3=NC(C4=C(C=CC=C5)C5=CC=C4)=CS3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (112.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2475 mL	11.2375 mL	22.4749 mL	112.3747 mL
5 mM	0.4495 mL	2.2475 mL	4.4950 mL	22.4749 mL
10 mM	0.2247 mL	1.1237 mL	2.2475 mL	11.2375 mL
20 mM	0.1124 mL	0.5619 mL	1.1237 mL	5.6187 mL
50 mM	0.0449 mL	0.2247 mL	0.4495 mL	2.2475 mL
100 mM	0.0225 mL	0.1124 mL	0.2247 mL	1.1237 mL

Calculator

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Dilution Calculator
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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc