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Anti-Insig2 Polyclonal Antibody
Catalog No. TMAB-07721 Copy Product Info
🥰Excellent
Anti-Insig2 Polyclonal Antibody is a Rabbit antibody targeting Insig2. Anti-Insig2 Polyclonal Antibody can be used in WB.
Anti-Insig2 Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-07721
Anti-Insig2 Polyclonal Antibody is a Rabbit antibody targeting Insig2. Anti-Insig2 Polyclonal Antibody can be used in WB.
Anti-Insig2 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-Insig2 Polyclonal Antibody is a Rabbit antibody targeting Insig2. Anti-Insig2 Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Dog,Pig,Cow,Horse,Sheep) |
| Verified Activity | Sample: Liver (Mouse) Lysate at 40 μg Primary: Anti-Insig2 (TMAB-07721) at 1/300 dilution Secondary: HRP conjugated Goat-Anti-rabbit IgG at 1/5000 dilution Predicted band size: 25 kD Observed band size: 23 kD |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Insig2 is highly similar to the protein product encoded by gene Insig1. Both Insig1 protein and Insig2 protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. |
| Immunogen | KLH conjugated synthetic peptide: human Insig2 |
| Antigen Species | Human |
| Gene Name | INSIG2 |
| Gene ID | |
| Protein Name | Insulin-induced gene 2 protein |
| Uniprot ID | |
| Function | Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR. |
| Molecular Weight | Theoretical: 25 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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