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Thalidomide-O-amido-C4-NH2 hydrochloride

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Catalog No. T18815Cas No. 2245697-86-1

Thalidomide-O-amido-C4-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate, combines the cereblon ligand derived from Thalidomide with a linker and is commonly used in the synthesis of PROTACs[1].

Thalidomide-O-amido-C4-NH2 hydrochloride

Thalidomide-O-amido-C4-NH2 hydrochloride

🥰Excellent
Catalog No. T18815Cas No. 2245697-86-1
Thalidomide-O-amido-C4-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate, combines the cereblon ligand derived from Thalidomide with a linker and is commonly used in the synthesis of PROTACs[1].
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Product Introduction

Bioactivity
Description
Thalidomide-O-amido-C4-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate, combines the cereblon ligand derived from Thalidomide with a linker and is commonly used in the synthesis of PROTACs[1].
In vitro
Thalidomide-O-amido-C4-NH2 (Compound 41) is an amine intermediate that serves as a heterobifunctional PROTAC BET degrader. BET family proteins (BRD2, BRD3, BRD4, and BRDT) are key epigenetic readers involved in gene transcription regulation and are therapeutic targets for cancer and other diseases. Heterobifunctional small-molecule BET degraders have been developed using the PROTAC approach to induce BET protein degradation[1]. Thalidomide-O-amido-C4-NH2 functions as a degron-linker (Compound DL6-TL), where the linker binds to at least one degron and targeting ligand. The degron can bind to an ubiquitin ligase such as cereblon, and the targeting ligand binds to the targeted proteins[2].
Chemical Properties
Molecular Weight438.86
FormulaC19H23ClN4O6
Cas No.2245697-86-1
SmilesCl.O=C(NCCCCN)COC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Thalidomide-O-amido-C4-NH2 HydrochlorideThalidomide-O-amido-C-4-NH2 hydrochlorideThalidomideOamidoC4NH2 hydrochlorideThalidomide O amido C4 NH2 hydrochlorideCereblon
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