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Nialamide
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Catalog No. T1455Cas No. 51-12-7
Alias Niamidal, Nialamid
Nialamide (Nialamid) is an MAO inhibitor that is used as an antidepressive agent.
Nialamide
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Catalog No. T1455Alias Niamidal, NialamidCas No. 51-12-7
Nialamide (Nialamid) is an MAO inhibitor that is used as an antidepressive agent.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $37 | - | In Stock | |
| 50 mg | $50 | Inquiry | Inquiry | |
| 1 mL x 10 mM (in DMSO) | $38 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Nialamide AI Summary
Nialamide exhibits a wide range of bioactivities and potential therapeutic effects. It has shown antiplasmodial activity against Plasmodium falciparum strains 3D7, HB3, and W2 with IC50 values of approximately 12589.25 nM and 15848.93 nM after 72 hours by SYBR green assay. Additionally, it has demonstrated antiviral activity against SARS-CoV-2, including inhibition of viral-induced cytotoxicity in VERO-6 and Caco-2 cells, and inhibition of the 3CL-Pro protease.
It is also active against other viruses, including the Marburg Virus and Ebola Virus. Nialamide exhibits inhibitory activity against various bacterial strains like Escherichia coli and Staphylococcus aureus MRSA, as well as antifungal activity against Candida albicans. In multiple cellular and biochemical assays, it targets a variety of molecular pathways and proteins, including the NFkB signaling pathway, Jumonji Domain containing 2E, Thyroid Stimulating Hormone Receptor, Tyrosyl-DNA Phosphodiesterase, and Histone Lysine Methyltransferase G9a.
On the downside, Nialamide is associated with potential hepatotoxicity, having been identified as DILI positive and showing moderate liver toxicity in clinical-chemistry assays. It induces drug-induced liver injury with a severity class index of 8.0. Overall, while Nialamide shows promise in targeting various disease pathways and cellular processes, its hepatotoxic potential necessitates careful consideration in therapeutic applications..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Nialamide (Nialamid) is an MAO inhibitor that is used as an antidepressive agent. |
| Synonyms | Niamidal, Nialamid |
| Molecular Weight | 298.34 |
| Formula | C16H18N4O2 |
| Cas No. | 51-12-7 |
| Smiles | O=C(CCNNC(=O)c1ccncc1)NCc1ccccc1 |
| Relative Density. | 1.1183 g/cm3 (Estimated) |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (100.56 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.7 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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