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S18-000003

Name: S18-000003
Brand: TargetMol
SKU: T16832
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16832Cas No. 2068119-11-7

S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production.

S18-000003

🥰Excellent

Purity: 99.31%

Catalog No. T16832Cas No. 2068119-11-7

S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production.

Pack Size	Price	Availability
1 mg	$52	In Stock
5 mg	$127	In Stock
10 mg	$198	In Stock
25 mg	$353	In Stock
50 mg	$495	In Stock
100 mg	$696	In Stock
500 mg	$1,390	In Stock
1 mL x 10 mM (in DMSO)	$145	In Stock

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Batch Information

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Purity:99.31%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production.
Targets&IC50	RORγt:29 nM

Chemical Properties

Molecular Weight	518.55
Formula	C₂₆H₂₅F₃N₂O₄S
Cas No.	2068119-11-7
Smiles	CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(c(F)c2)C(C)(C)C(=O)Nc2ccc(F)cc2F)cc1
Relative Density.	1.358 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (192.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9285 mL	9.6423 mL	19.2845 mL	96.4227 mL
5 mM	0.3857 mL	1.9285 mL	3.8569 mL	19.2845 mL
10 mM	0.1928 mL	0.9642 mL	1.9285 mL	9.6423 mL
20 mM	0.0964 mL	0.4821 mL	0.9642 mL	4.8211 mL
50 mM	0.0386 mL	0.1928 mL	0.3857 mL	1.9285 mL
100 mM	0.0193 mL	0.0964 mL	0.1928 mL	0.9642 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc