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S18-000003

Name: S18-000003
Brand: TargetMol
SKU: T16832
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16832Cas No. 2068119-11-7

S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production.

S18-000003

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Purity: 99.31%

Catalog No. T16832Cas No. 2068119-11-7

S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	In Stock	In Stock
5 mg	$127	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$353	In Stock	In Stock
50 mg	$495	In Stock	In Stock
100 mg	$696	In Stock	In Stock
500 mg	$1,390	-	In Stock
1 mL x 10 mM (in DMSO)	$145	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.31%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

S18-000003 AI Summary

S18-000003 demonstrates bioactivities related to the transrepression of RORgammat, exhibiting varying degrees of potency in different assays. It effectively suppresses T cell differentiation to Th17 cells by reducing IL-17A levels in both mouse and human CD4-positive T cells. The compound shows transrepressive activity via luciferase reporter gene assays and displaces [3H]-Digoxin from recombinant human GST-fused RORgammat LBD. It also exhibits stability in human and rat liver microsomes and has good solubility in buffer solutions. In in-vivo studies with mice, S18-000003 inhibits IL23-stimulated IL17 production at different dosages, indicating potential anti-inflammatory effects..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production.
Targets&IC50	RORγt:29 nM

Chemical Properties

Molecular Weight	518.55
Formula	C₂₆H₂₅F₃N₂O₄S
Cas No.	2068119-11-7
Smiles	CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(c(F)c2)C(C)(C)C(=O)Nc2ccc(F)cc2F)cc1
Relative Density.	1.358 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (192.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9285 mL	9.6423 mL	19.2845 mL	96.4227 mL
5 mM	0.3857 mL	1.9285 mL	3.8569 mL	19.2845 mL
10 mM	0.1928 mL	0.9642 mL	1.9285 mL	9.6423 mL
20 mM	0.0964 mL	0.4821 mL	0.9642 mL	4.8211 mL
50 mM	0.0386 mL	0.1928 mL	0.3857 mL	1.9285 mL
100 mM	0.0193 mL	0.0964 mL	0.1928 mL	0.9642 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc