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DNA Methyltransferase

DNA methyltransferases are a group of enzymes involved in the regulation of gene expression. DNA methyltransferases cause the aberrant DNA methylation of tumor suppressor genes, which become hypermethylated and transcriptionally silent in some blood cancers.

  • Decitabine
    T15082353-33-5
    Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis.
    • $30
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    TargetMol | Citations Cited
  • Procainamide hydrochloride
    T0018614-39-1
    Procainamide Hydrochloride (Procapan) is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks the influx of sodium ions into the cell, which leads to an increase in threshold for excitation and inhibit depolarization during phase 0 of the action potential.
    • $41
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  • γ-Oryzanol
    T360611042-64-1
    γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the destruction of free radicals in the skin. It has recently been researched for its ability to slow the progress of melanin pigmentation by intercepting the ultraviolet rays at the skin's surface and hindering their transmission.
    • $41
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  • Levetiracetam
    T0192102767-28-2
    Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum aminotransferase and alkaline phosphatase elevations during treatment and to rare cases of clinically apparent drug induced liver disease.
    • $50
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  • 5-Methyl-2'-deoxycytidine
    T7457838-07-3
    5-Methyl-2'-deoxycytidine (5MedCyd) is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo.
    • $35
    In Stock
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  • 2’-Deoxy-2’-fluoro-β-D-arabinocytidine hydrochloride
    TNU042525183-22-6
    2’-Deoxy-2’-fluoro-β-D-arabinocytidine hydrochloride is a cytosine nucleoside analog with inhibitory effects on DNA methyltransferase , with potential antimetabolic and antitumor activity.
    • $195
    In Stock
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    TargetMol | Inhibitor Sale
  • CM-579
    T10840L1846570-40-8In house
    CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
    • $50
    In Stock
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  • GSK-3484862
    T114692170136-65-7In house
    GSK-3484862 is a non-covalent Dnmt1 inhibitor. It induces DNA hypomethylation to against cancer.
    • $43
    In Stock
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  • Dihydro-5-azacytidine
    T4071362488-57-7In house
    Dihydro-5-azacytidine (DHAC) is an active nucleoside analog with anti-leukemic activity that inhibits cell growth and induces DNA hypomethylation.Dihydro-5-azacytidine is used in the study of leukemia and tumors.
    • $1,520
    Backorder
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  • RG108
    T203848208-26-0
    RG108 (N-Phthalyl-L-tryptophan) is an DNA methyltransferase inhibitor(IC50=115 nM).
    • $39
    In Stock
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    TargetMol | Citations Cited
  • 5-Azacytidine
    T1339320-67-2
    5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity. 5-Azacytidine regulates gene expression by decreasing the level of DNA methylation. 5-Azacytidine induces autophagy and has antitumor activity.
    • $33
    In Stock
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    TargetMol | Citations Cited
  • Bobcat339
    T51982280037-51-4
    Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
    • $47
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    TargetMol | Citations Cited
  • SGI-1027
    T19041020149-73-8
    SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027(SGI1027) against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, respectively.
    • $53
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    TargetMol | Citations Cited
  • 6-Thioguanine
    T3089154-42-7
    6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
    • $40
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    TargetMol | Citations Cited
  • Dihydro-5-azacytidine FA
    T40713L
    Dihydro-5-azacytidine FA (DHAC) is a pyrimidine analog that has antitumor activity, inhibits cell growth, inhibits DNA methylation, and may be used in the study of malignant mesothelioma.
    • $195
    In Stock
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    TargetMol | Inhibitor Sale
  • CM-579 trihydrochloride (1846570-40-8 free base)
    T10840
    CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide range of cancer cells.
    • $223
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    TargetMol | Inhibitor Sale
  • 2',3',5'-triacetyl-5-Azacytidine
    T784010302-78-0
    2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.
    • $41
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  • TFMB-(S)-2-HG
    T248711445703-64-9
    TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase. Additionally, it significantly inhibits the EglN prolyl hydroxylases. With its unique properties, TFMB-(S)-2-HG holds great promise for advancing research in the field of acute myeloid leukemia (AML).
    • $30
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  • Guadecitabine sodium
    T12790929904-85-8
    Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .
    • $1,670
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  • Tetrahydrouridine
    T1705918771-50-1
    Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator. It can be used in cancer treatment to make tumor cells more sensitive to radiation therapy. THU is a competitive cytidine deaminase(CDA) inhibitor that inhibits deamination in the catabolism of cytotoxic deoxycytidine analogs such as ara-C and Gemcitabine.
    • Inquiry Price
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  • Hinokitiol
    T3717499-44-5
    Hinokitiol (4-Isopropyltropolone) can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity of metallothionein induced by the agent. Also, Hinokitiol modulates estrogen receptor signaling and inhibits proliferation of human breast cancer cells.
    • $31
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  • Zebularine
    T21693690-10-6
    Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. It also inhibits cytidine deaminase (Ki: 2 μM, in a cell-free assay).
    • $38
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  • DC-05
    T15080890643-16-0
    DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).
    • $132
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  • 5-Fluoro-2'-deoxycytidine
    T771810356-76-0
    5-Fluoro-2'-deoxycytidine (2'-DEOXY-5-FLUOROCYTIDINE) is an inhibitor of DNA methyltransferase (DNMT) .
    • $30
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  • GSK3685032
    T95732170137-61-6
    GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM). The inhibitory effect is time-independent and reversible. GSK3685032 induces loss of DNA methylation and transcriptional activation and inhibits cancer cell growth.
    • $94
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  • Isomaltotriose
    T193833371-50-4
    Isomaltotriose is a sugar compound derived from the enzymic hydrolyzates of dextran obtained from the Leuconostoc mesenteroides NRRL B-512.
      7-10 days
      Inquiry
    • SW155246
      T8967420092-79-1
      SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.
      • $43
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    • Neurodazine
      T16287937807-66-4
      Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.Neurodazine promotes differentiation by activating Wnt and Shh signaling.
      • $52
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    • Nanaomycin A
      T1626952934-83-5
      Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).
      • $370
      35 days
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    • Lomeguatrib
      T2495192441-08-0
      Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
      • $43
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    • CM-272
      T71941846570-31-7
      CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
      • $67
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    • DC_517
      T15081500017-70-9
      DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).
      • $198
      Backorder
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    • Procainamide
      T6032251-06-9
      Procainamide (Novocainamide) is a specific and potent DNA methyltransferase 1 ( DNMT1 ) inhibitor. Procainamide is a Class 1A antiarrhythmic agent. Procainamide has the potential for the research of cancer and arrhythmias [1] [2].
      • $30
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    • Cedazuridine
      T269721141397-80-9
      Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.
      • $50
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