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Methyltetrazine-PEG8-NHS ester

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Catalog No. T16062Cas No. 2183440-34-6

Methyltetrazine-PEG8-NHS ester is a polyethylene glycol (PEG) derivative specifically designed as a PROTAC linker for synthesizing Proteolysis Targeting Chimeras (PROTACs)[1].

Methyltetrazine-PEG8-NHS ester

Methyltetrazine-PEG8-NHS ester

😃Good
Catalog No. T16062Cas No. 2183440-34-6
Methyltetrazine-PEG8-NHS ester is a polyethylene glycol (PEG) derivative specifically designed as a PROTAC linker for synthesizing Proteolysis Targeting Chimeras (PROTACs)[1].
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
Methyltetrazine-PEG8-NHS ester is a polyethylene glycol (PEG) derivative specifically designed as a PROTAC linker for synthesizing Proteolysis Targeting Chimeras (PROTACs)[1].
In vitro
PROTACs are bifunctional molecules composed of two ligands, one binding to an E3 ubiquitin ligase and the other to a target protein, connected by a linker. They harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].
Chemical Properties
Molecular Weight709.74
FormulaC32H47N5O13
Cas No.2183440-34-6
SmilesO=C(ON1C(=O)CCC1=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOC=2C=CC(=CC2)C3=NN=C(N=N3)C
Relative Density.1.29 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PEGsMethyltetrazine-PEG8-NHS esterMethyltetrazine-PEG-8-NHS esterMethyltetrazinePEG8NHS esterMethyltetrazine PEG8 NHS ester
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