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IL-3R alpha/CD123 Protein, Mouse, Recombinant (aa 17-331, His)

Catalog No. TMPJ-00251
Synonyms: IL-3 receptor subunit alpha, IL-3R subunit α, Interleukin-3 receptor subunit alpha, Interleukin-3 receptor subunit α, IL-3 receptor subunit α, IL-3RA, IL-3R-alpha, IL-3R subunit alpha, IL-3R-α

CD123, also known as Interleukin-3 receptor subunit alpha, belongs to the type I cytokine receptor family. In mouse, there are two classes of high-affinity IL3 receptors. One contains an IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors. CD123 stimulates the proliferation and differentiation of hemopoietic cells including the pluripotent hematopoietic stem cells as well as various lineage‑committed cells. CD123 is a heterodimer consisting of an alpha and a beta subunit. The alpha subunit alone binds IL‑3 with low affinity. The beta subunit does not bind IL‑3 by itself but is required for the high‑affinity binding of IL‑3 to the heterodimeric receptor complex.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
IL-3R alpha/CD123 Protein, Mouse, Recombinant (aa 17-331, His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 68.00
50 μg 5 days $ 207.00
500 μg 5 days $ 1,840.00
1 mg 5 days $ 2,770.00
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Biological Description
Technical Params
Product Properties
Description CD123, also known as Interleukin-3 receptor subunit alpha, belongs to the type I cytokine receptor family. In mouse, there are two classes of high-affinity IL3 receptors. One contains an IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors. CD123 stimulates the proliferation and differentiation of hemopoietic cells including the pluripotent hematopoietic stem cells as well as various lineage‑committed cells. CD123 is a heterodimer consisting of an alpha and a beta subunit. The alpha subunit alone binds IL‑3 with low affinity. The beta subunit does not bind IL‑3 by itself but is required for the high‑affinity binding of IL‑3 to the heterodimeric receptor complex.
Species Mouse
Expression System Human Cells
Tag C-8His
Accession Number P26952
Synonyms IL-3 receptor subunit alpha, IL-3R subunit α, Interleukin-3 receptor subunit alpha, Interleukin-3 receptor subunit α, IL-3 receptor subunit α, IL-3RA, IL-3R-alpha, IL-3R subunit alpha, IL-3R-α
Amino Acid Ser17-Lys331
Construction Recombinant Mouse Interleukin-3 Receptor Subunit Alpha is produced by our Mammalian expression system and the target gene encoding Ser17-Lys331 is expressed with a 8His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 50-65 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background CD123, also known as Interleukin-3 receptor subunit alpha, belongs to the type I cytokine receptor family. In mouse, there are two classes of high-affinity IL3 receptors. One contains an IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors. CD123 stimulates the proliferation and differentiation of hemopoietic cells including the pluripotent hematopoietic stem cells as well as various lineage‑committed cells. CD123 is a heterodimer consisting of an alpha and a beta subunit. The alpha subunit alone binds IL‑3 with low affinity. The beta subunit does not bind IL‑3 by itself but is required for the high‑affinity binding of IL‑3 to the heterodimeric receptor complex.

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Keywords

IL-3R alpha/CD123 Protein, Mouse, Recombinant (aa 17-331, His) IL-3 receptor subunit alpha IL-3R subunit α Interleukin-3 receptor subunit alpha Interleukin-3 receptor subunit α IL-3 receptor subunit α IL-3RA IL-3R-alpha IL-3R subunit alpha IL-3R-α recombinant recombinant-proteins proteins protein

 

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