Shopping Cart
Remove All
Your shopping cart is currently empty
MRS-1706
Copy Product Info
😃Good
Catalog No. T16136Cas No. 264622-53-9
MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1, and A3 receptors respectively. MRS-1706 is an effective and selective adenosine A2B receptor inverse agonist.
MRS-1706
Copy Product Info😃Good
Purity: 99.00%
Catalog No. T16136Cas No. 264622-53-9
MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1, and A3 receptors respectively. MRS-1706 is an effective and selective adenosine A2B receptor inverse agonist.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $31 | In Stock | In Stock | |
| 5 mg | $72 | In Stock | In Stock | |
| 10 mg | $122 | In Stock | In Stock | |
| 25 mg | $247 | In Stock | In Stock | |
| 50 mg | $396 | In Stock | In Stock | |
| 100 mg | $635 | - | In Stock | |
| 200 mg | $893 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $80 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.00%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
MRS-1706 AI Summary
MRS-1706 exhibits a range of bioactivities related to both adenosine receptors and cytochrome P450 enzymes. It acts as an antagonist on various adenosine receptor subtypes, including A1, A2A, A2B, and A3, with Ki values of 157.0 nM, 112.0 nM, 1.39 nM, and 230.0 nM, respectively. The highest affinity is observed for the A2B adenosine receptor. Selectivity ratios indicate a notable preference for the A3 receptor over the A2B receptor, with a ratio of 170.0, suggesting significant potential pharmacological effects mediated through adenosine receptor modulation.
In addition, MRS-1706 shows inhibitory effects on cytochrome P450 enzymes, specifically 2C19, 2D6, and 2C9. It demonstrates potent inhibition of Cytochrome P450 2D6 with an IC50 of 100.0 nM, and less potent inhibition of Cytochrome P450 2C9 with an IC50 of 39810.7 nM. In panel assays, it has AC50 values of 7943.28 nM for 2C19 and 39810.72 nM for 2C9, confirming its activity against these enzymes.
These properties suggest that MRS-1706 could have various therapeutic applications through adenosine receptor antagonism and cytochrome P450 enzyme inhibition..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1, and A3 receptors respectively. MRS-1706 is an effective and selective adenosine A2B receptor inverse agonist. |
| Targets&IC50 | A2 receptor (human):157(ki), A2A receptor (human):112(ki), A2B receptor (human):(ki)1.39 , A3 receptor (human):230 nM |
| Molecular Weight | 503.55 |
| Formula | C27H29N5O5 |
| Cas No. | 264622-53-9 |
| Smiles | CCCn1c2[nH]c(nc2c(=O)n(CCC)c1=O)-c1ccc(OCC(=O)Nc2ccc(cc2)C(C)=O)cc1 |
| Relative Density. | 1.293 g/cm3 (Predicted) |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 6.4 mg/mL (12.71 mM), Sonication and heating are recommended. H2O: < 0.1 mg/mL (insoluble) | ||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.99 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
| |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy MRS-1706 | purchase MRS-1706 | MRS-1706 cost | order MRS-1706 | MRS-1706 chemical structure | MRS-1706 formula | MRS-1706 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.