Dichlorphenamide disodium is a specific, orally active carbonic anhydrase inhibitor. It effectively reduces intraocular pressure by impeding the secretion of aqueous humor. Notably, dichlorphenamide disodium holds potential for glaucoma research [1].

Dichlorphenamide disodium has been shown to significantly reduce intraocular pressure (IOP) in male albino rabbits when applied locally. In this study, rabbits weighing approximately 2.5 kg received either a 50 μL eye drop or oral gavage of dichlorphenamide sodium, at dosages of 50 μL of a 10% aqueous solution or 2 mg/kg and 6 mg/kg, respectively. Results indicated a remarkable decrease in IOP as early as 30 minutes post-application for the eye drops, and at one hour post-administration for the oral gavage. Additionally, the concentration of the drug was significantly higher in the iris-ciliary body and lower in the serum when administered as an eye drop compared to orally, demonstrating a more direct and effective method of reducing IOP locally.