Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dichlorphenamide disodium is a specific, orally active carbonic anhydrase inhibitor. It effectively reduces intraocular pressure by impeding the secretion of aqueous humor. Notably, dichlorphenamide disodium holds potential for glaucoma research [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,520.00 | |
50 mg | 10-14 weeks | $ 1,980.00 | |
100 mg | 10-14 weeks | $ 2,500.00 |
Description | Dichlorphenamide disodium is a specific, orally active carbonic anhydrase inhibitor. It effectively reduces intraocular pressure by impeding the secretion of aqueous humor. Notably, dichlorphenamide disodium holds potential for glaucoma research [1]. |
In vivo | Dichlorphenamide disodium has been shown to significantly reduce intraocular pressure (IOP) in male albino rabbits when applied locally. In this study, rabbits weighing approximately 2.5 kg received either a 50 μL eye drop or oral gavage of dichlorphenamide sodium, at dosages of 50 μL of a 10% aqueous solution or 2 mg/kg and 6 mg/kg, respectively. Results indicated a remarkable decrease in IOP as early as 30 minutes post-application for the eye drops, and at one hour post-administration for the oral gavage. Additionally, the concentration of the drug was significantly higher in the iris-ciliary body and lower in the serum when administered as an eye drop compared to orally, demonstrating a more direct and effective method of reducing IOP locally. |
Molecular Weight | 351.12 |
Formula | C6H6Cl2N2Na2O4S2 |
CAS No. | 76382-13-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Dichlorphenamide disodium 76382-13-3 inhibitor inhibit