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BI-0474

Catalog No. T69529 CAS 2750570-55-7

BI-0474 is a potent KRASG12C inhibitor that inhibits GDP-KRAS::SOS1 protein-protein interactions with an IC50 value of 7.0 nM.BI-0474 exhibits significant antiproliferative activity against NCI-H358 cells harboring the G12C mutation, and shows significant anti-tumor activity in a non-small cell lung cancer xenograft model. activity.BI-0474 can be used for cancer research.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

BI-0474, CAS 2750570-55-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 432.00
5 mg	In stock	$ 987.00
10 mg	In stock	$ 1,370.00
25 mg	In stock	$ 1,980.00
50 mg	In stock	$ 2,730.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BI-0474 is a potent KRASG12C inhibitor that inhibits GDP-KRAS::SOS1 protein-protein interactions with an IC50 value of 7.0 nM.BI-0474 exhibits significant antiproliferative activity against NCI-H358 cells harboring the G12C mutation, and shows significant anti-tumor activity in a non-small cell lung cancer xenograft model. activity.BI-0474 can be used for cancer research.
Targets&IC50	KRAS-SOS1:7 nM
In vitro	BI-0474 (1-10,000 nM; 3 days; NCI-H358 cells carrying a G12C mutation) inhibited proliferation of NCI-H358 cells with an EC50 of 26 nM.[1]
In vivo	BI-0474 (40 mg/kg; i.p.; single daily for 3 days; NMRI nude mice) shows anti-tumor efficacy and pharmacodynamic biomarker modulation. This led to the induction of programmed cell death in this xenograft model.[1]

Molecular Weight	587.74
Formula	C30H37N9O2S
CAS No.	2750570-55-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Bröker J, et al. Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor. J Med Chem. 2022 Oct 27.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Membrane Protein-targeted Compound Library Inhibitor Library GPCR Compound Library Bioactive Compounds Library Max Bioactive Compound Library

Related Products

Related compounds with same targets

KRAS inhibitor-8 BQU57 (Rac)-Antineoplaston A10 Kras4B G12D-IN-1 KRas G12C inhibitor 2 Pan-RAS-IN-1 Rhosin hydrochloride MRTX-1257

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BI-0474 2750570-55-7 GPCR/G Protein MAPK Ras inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.