Shopping Cart
- Remove All
Your shopping cart is currently empty
Anti-Phospho-PTEN (Ser380, Thr382, 383) Polyclonal Antibody
😃Good
Catalog No. TMAC-03463
Alias TEP1, PTEN1, PTEN (p-Ser380, Thr382, 383), PTEN (p-S380, T382, 383), p-PTEN (Ser380, Thr382, 383), p-PTEN (S380, T382, 383), Phospho-PTEN (S380, T382, 383), Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin like protein, Phosphatase and tensin homolog, Mutated in multiple advanced cancers 1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MMAC1, MHAM, MGC11227, GLM2, DEC, BZS, 10q23del
Anti-Phospho-PTEN (Ser380, Thr382, 383) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PTEN (Ser380, Thr382, 383). Anti-Phospho-PTEN (Ser380, Thr382, 383) Polyclonal Antibody can be used in IF,IHC,WB.
Anti-Phospho-PTEN (Ser380, Thr382, 383) Polyclonal Antibody
Anti-Phospho-PTEN (Ser380, Thr382, 383) Polyclonal Antibody
😃Good
Catalog No. TMAC-03463Alias TEP1, PTEN1, PTEN (p-Ser380, Thr382, 383), PTEN (p-S380, T382, 383), p-PTEN (Ser380, Thr382, 383), p-PTEN (S380, T382, 383), Phospho-PTEN (S380, T382, 383), Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin like protein, Phosphatase and tensin homolog, Mutated in multiple advanced cancers 1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MMAC1, MHAM, MGC11227, GLM2, DEC, BZS, 10q23del
Anti-Phospho-PTEN (Ser380, Thr382, 383) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PTEN (Ser380, Thr382, 383). Anti-Phospho-PTEN (Ser380, Thr382, 383) Polyclonal Antibody can be used in IF,IHC,WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $218 | 7-10 days | |
| 100 μL | $317 | 7-10 days |
Add to Cart
Add to Quotation
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
View MoreResource Download
Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Phospho-PTEN (Ser380, Thr382, 383) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PTEN (Ser380, Thr382, 383). Anti-Phospho-PTEN (Ser380, Thr382, 383) Polyclonal Antibody can be used in IF,IHC,WB. |
| Synonyms | TEP1, PTEN1, PTEN (p-Ser380, Thr382, 383), PTEN (p-S380, T382, 383), p-PTEN (Ser380, Thr382, 383), p-PTEN (S380, T382, 383), Phospho-PTEN (S380, T382, 383), Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin like protein, Phosphatase and tensin homolog, Mutated in multiple advanced cancers 1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MMAC1, MHAM, MGC11227, GLM2, DEC, BZS, 10q23del |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using PTEN (Phospho-Ser380/Thr382/Thr383) Antibody TMAC-03463 (left) or the same antibody preincubated with blocking peptide (right). 2. Immunofluorescence staining of methanol-fixed Hela cells using PTEN (Phospho-Ser380/Thr382/Thr383) Antibody TMAC-03463. 3. Western blot analysis of extracts from Hela cells, treated with IFNa or calf intestinal phosphatase (CIP), using PTEN (Phospho-Ser380/Thr382/Thr383) Antibody TMAC-03463. 4. Western blot analysis of extracts from Hela and C6 cells,treated with EGF or PMA, using PTEN (Phospho-Ser380/Thr382/Thr383) Antibody TMAC-03463. 5. Immunofluorescence staining of methanol-fixed MEFcells using PTEN (Phospho-Ser380/Thr382/Thr383)Antibody TMAC-03463. |
| Application | |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of threonine 380/382/383 (R-Y-S(p)-D-T(p)-T(p)-D-S) derived from Human PTEN |
| Antigen Species | human |
| Uniprot ID |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Calculator
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Anti-Phospho-PTEN (Ser380, Thr382, 383) Polyclonal Antibody | purchase Anti-Phospho-PTEN (Ser380, Thr382, 383) Polyclonal Antibody | Anti-Phospho-PTEN (Ser380, Thr382, 383) Polyclonal Antibody cost | order Anti-Phospho-PTEN (Ser380, Thr382, 383) Polyclonal Antibody
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.