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MAL-di-EG-Val-Cit-PAB-MMAF

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Catalog No. T18251

MAL-di-EG-Val-Cit-PAB-MMAF is a chemical compound consisting of the linker (MAL-di-EG-Val-Cit-PAB) and the potent tubulin polymerization inhibitor (MMAF, Monomethyl auristatin F) [1].

MAL-di-EG-Val-Cit-PAB-MMAF

MAL-di-EG-Val-Cit-PAB-MMAF

😃Good
Catalog No. T18251
MAL-di-EG-Val-Cit-PAB-MMAF is a chemical compound consisting of the linker (MAL-di-EG-Val-Cit-PAB) and the potent tubulin polymerization inhibitor (MMAF, Monomethyl auristatin F) [1].
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
MAL-di-EG-Val-Cit-PAB-MMAF is a chemical compound consisting of the linker (MAL-di-EG-Val-Cit-PAB) and the potent tubulin polymerization inhibitor (MMAF, Monomethyl auristatin F) [1].
Chemical Properties
Molecular Weight1476.75
FormulaC73H113N13O19
SmilesCN([C@H](C(N[C@H](C(N([C@H]([C@@H](CC(N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(N[C@@H](CC2=CC=CC=C2)C(O)=O)=O)=O)OC)[C@H](CC)C)C)=O)C(C)C)=O)C(C)C)N(C)C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCNC(CCN4C(C=CC4=O)=O)=O)=O)=O)=O)C=C3)=O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 230 mg/mL (155.75 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.6772 mL3.3858 mL6.7716 mL33.8581 mL
5 mM0.1354 mL0.6772 mL1.3543 mL6.7716 mL
10 mM0.0677 mL0.3386 mL0.6772 mL3.3858 mL
20 mM0.0339 mL0.1693 mL0.3386 mL1.6929 mL
50 mM0.0135 mL0.0677 mL0.1354 mL0.6772 mL
100 mM0.0068 mL0.0339 mL0.0677 mL0.3386 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MAL-di-EG-Val-Cit-PAB-MMAFMALdiEGValCitPABMMAFMAL di EG Val Cit PAB MMAFDrugLinkerConjugatesforADCDrugLinker Conjugates for ADCAuristatin
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