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CL 316243

Name: CL 316243
Brand: TargetMol
SKU: T10830
Price: 555 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10830Cas No. 138908-40-4

CL316243 is a highly potent selective agonist of β3-adrenoceptor, with a EC50 of 3 nM. CL316243 is an effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence.

CL 316243

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Purity: 99.68%

Catalog No. T10830Cas No. 138908-40-4

Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$113	In Stock
10 mg	$172	In Stock
25 mg	$347	In Stock
50 mg	$555	In Stock
100 mg	Inquiry	In Stock
500 mg	Inquiry	6-8 weeks

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.68%

ee:100%

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COA HPLC HNMR CSFC ORP

Product Introduction

Bioactivity

Description	CL316243 is a highly potent selective agonist of β3-adrenoceptor, with a EC50 of 3 nM. CL316243 is an effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence.
Targets&IC50	β3-adrenoceptor:3 nM (EC50)
In vitro	METHODS: We treated rat adipocytes with CL (0.001 - 1 μM) and examined MAPK activation. RESULTS Treatment of cells with CL for 15 min activated MAPK, but the increase in MAPK activation was not obvious when treated with 1 nM CL, and disappeared when the concentration of CL was increased to 1 μM. [2]
In vivo	METHODS: The relaxant effects of different concentrations of CL316243 (0.25-100 g/kg) on the rat lower esophageal sphincter (LES) were recorded before and after continuous infusion of L748337 (0.5 g kg1 min1). RESULTS CL316243 had a significant, long-term and dose-dependent inhibitory effect on LESP, with little effect on heart rate and mean arterial pressure. [1]

Chemical Properties

Molecular Weight	465.79
Formula	C₂₀H₁₈ClNNa₂O₇
Cas No.	138908-40-4
Smiles	[Na+].[Na+].C[C@H](Cc1ccc2OC(Oc2c1)(C([O-])=O)C([O-])=O)NC[C@H](O)c1cccc(Cl)c1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (21.47 mM), Sonication is recommended.

H2O: 100 mg/mL (214.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.1469 mL	10.7345 mL	21.4689 mL	107.3445 mL
5 mM	0.4294 mL	2.1469 mL	4.2938 mL	21.4689 mL
10 mM	0.2147 mL	1.0734 mL	2.1469 mL	10.7345 mL
20 mM	0.1073 mL	0.5367 mL	1.0734 mL	5.3672 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0429 mL	0.2147 mL	0.4294 mL	2.1469 mL
100 mM	0.0215 mL	0.1073 mL	0.2147 mL	1.0734 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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