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CL 316243

Name: CL 316243
Brand: TargetMol
SKU: T10830
Price: 555 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10830Cas No. 138908-40-4

CL316243 is a highly potent selective agonist of β3-adrenoceptor, with a EC50 of 3 nM. CL316243 is an effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence.

CL 316243

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Purity: 99.68%

Catalog No. T10830Cas No. 138908-40-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$172	In Stock	In Stock
25 mg	$347	In Stock	-
50 mg	$555	6-8 weeks	6-8 weeks
100 mg	Inquiry	6-8 weeks	6-8 weeks
500 mg	Inquiry	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.68%

ee:100%

Appearance:Solid

Color:White to Yellow

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COA HPLC HNMR ORP CSFC

Product Introduction

Bioactivity

Description	CL316243 is a highly potent selective agonist of β3-adrenoceptor, with a EC50 of 3 nM. CL316243 is an effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence.
Targets&IC50	β3-adrenoceptor:3 nM (EC50)
In vitro	METHODS: We treated rat adipocytes with CL (0.001 - 1 μM) and examined MAPK activation. RESULTS Treatment of cells with CL for 15 min activated MAPK, but the increase in MAPK activation was not obvious when treated with 1 nM CL, and disappeared when the concentration of CL was increased to 1 μM. [2]
In vivo	METHODS: The relaxant effects of different concentrations of CL316243 (0.25-100 g/kg) on the rat lower esophageal sphincter (LES) were recorded before and after continuous infusion of L748337 (0.5 g kg1 min1). RESULTS CL316243 had a significant, long-term and dose-dependent inhibitory effect on LESP, with little effect on heart rate and mean arterial pressure. [1]

Chemical Properties

Molecular Weight	465.79
Formula	C₂₀H₁₈ClNNa₂O₇
Cas No.	138908-40-4
Smiles	[Na+].[Na+].C[C@H](Cc1ccc2OC(Oc2c1)(C([O-])=O)C([O-])=O)NC[C@H](O)c1cccc(Cl)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (21.47 mM), Sonication is recommended.

H2O: 100 mg/mL (214.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.1469 mL	10.7345 mL	21.4689 mL	107.3445 mL
5 mM	0.4294 mL	2.1469 mL	4.2938 mL	21.4689 mL
10 mM	0.2147 mL	1.0734 mL	2.1469 mL	10.7345 mL
20 mM	0.1073 mL	0.5367 mL	1.0734 mL	5.3672 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0429 mL	0.2147 mL	0.4294 mL	2.1469 mL
100 mM	0.0215 mL	0.1073 mL	0.2147 mL	1.0734 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc