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Naphazoline
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Catalog No. T21445Cas No. 835-31-4
Alias Naphcon-a, Clear Eyes, All Clear, AK-Con
Naphazoline (Naphcon-a) is a sympathomimetic compound with marked alpha adrenergic activity. Naphazoline can be used as a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane.
Naphazoline
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Purity: 99.79%
Catalog No. T21445Alias Naphcon-a, Clear Eyes, All Clear, AK-ConCas No. 835-31-4
Naphazoline (Naphcon-a) is a sympathomimetic compound with marked alpha adrenergic activity. Naphazoline can be used as a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $40 | In Stock | In Stock | |
| 10 mg | $56 | In Stock | In Stock | |
| 25 mg | $93 | In Stock | In Stock | |
| 50 mg | $137 | In Stock | In Stock | |
| 100 mg | $198 | In Stock | In Stock | |
| 200 mg | $296 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.79%
Appearance:Solid
Color:White
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Product Introduction
Naphazoline AI Summary
Naphazoline demonstrates a complex pharmacological profile with both hypotensive and hypertensive activities. In normotensive rats, it causes a 25% decrease in arterial pressure after intravenous administration due to hypotensive effects, while in pithed rats, it leads to an increase in arterial pressure. The compound exhibits significant binding affinities for alpha-1 adrenergic receptors (alpha-1A, alpha-1B, and alpha-1D) and alpha-2 adrenergic receptors, with notable EC50 and Ki values. Specifically, Naphazoline acts as a potent agonist for the human alpha-1A adrenoceptor (EC50 of 63.1 nM) and demonstrates efficacy in alpha-1 receptor subtypes with EC50 values below 5011.87 nM. It also exhibits antagonistic properties against the alpha-2 adrenergic receptor in rat brain membranes (Ki of 5.7 nM).
The compound shows binding affinity to various adrenergic receptors, including a high binding affinity to the I2 and I1 imidazoline binding sites. Its partition coefficient at pH 7.4 is -0.52, indicating its distribution between octanol and buffer.
Bioactivity studies reveal that Naphazoline has several additional effects, including modulation of lamin A splicing, inhibition of tau fibril formation, ERK signaling pathways, and activity in Cytochrome P450 2D6 assays. Despite these activities, it has shown no hepatic side effects, based on the Drug Induced Liver Injury Prediction System (DILIps).
Further antiviral research indicates that Naphazoline inhibits the SARS-CoV-2 3CL-Pro protease and demonstrates antiviral activity against the SARS-CoV-2 virus in VERO-6 cells. However, the potency of its antiviral effects is relatively low (IC50 values > 20000.0 nM).
In addition, the compound demonstrates inhibitory activity against human HDAC6 and interacts with various other human receptors, exhibiting both antagonist and agonist activities. The compound's pKa value of 10.3 indicates a strong basic character, influencing its bioactivity in pH-dependent processes.
Overall, Naphazoline holds potential for diverse pharmacological applications due to its multifaceted bioactivities, particularly in modulating adrenergic signaling pathways and exhibiting antiviral properties..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Naphazoline (Naphcon-a) is a sympathomimetic compound with marked alpha adrenergic activity. Naphazoline can be used as a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane. |
| Synonyms | Naphcon-a, Clear Eyes, All Clear, AK-Con |
| Molecular Weight | 210.27 |
| Formula | C14H14N2 |
| Cas No. | 835-31-4 |
| Smiles | C(C1=NCCN1)C1=CC=CC2=CC=CC=C12 |
| Relative Density. | 1.1063 g/cm3 (Estimated) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (237.79 mM), Sonication is recommended.  H2O: Insoluble | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
α-adrenergic receptorVEGFRvasoconstrictionvascular hyperpermeabilityVascular endothelial growth factor receptorTumor Necrosis Factor ReceptorTNFRTNF ReceptorNaphthazolineNaphazolineInterleukin RelatedInhibitorinhibitinflammationdecongestivecytokinesconjunctivitisBeta ReceptorAdrenergicReceptorAdrenergic Receptor
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