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Anti-p53BP1 Polyclonal Antibody
😃Good
Catalog No. TMAB-01322
Anti-p53BP1 Polyclonal Antibody is a Rabbit antibody targeting p53BP1. Anti-p53BP1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,ICC/IF.
Anti-p53BP1 Polyclonal Antibody
Anti-p53BP1 Polyclonal Antibody
😃Good
Catalog No. TMAB-01322
Anti-p53BP1 Polyclonal Antibody is a Rabbit antibody targeting p53BP1. Anti-p53BP1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $220 | 7-10 days | |
| 100 μL | $373 | 7-10 days | |
| 200 μL | $527 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-p53BP1 Polyclonal Antibody is a Rabbit antibody targeting p53BP1. Anti-p53BP1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,ICC/IF. |
| Ig Type | IgG |
| Reactivity | Human,Rat (predicted:Mouse,Dog,Rabbit) |
| Verified Activity | 1. Tissue/cell: rat colon tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer (0.01M, pH6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37°C for 20 min; Incubation: Anti-p53BP1 Polyclonal Antibody, Unconjugated (TMAB-01322) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody and DAb staining. 2. 4% Paraformaldehyde-fixed Hela (H) cell; Triton X-100 at RT for 20 min; Antibody incubation with (p53BP1) polyclonal Antibody, unconjugated (TMAB-01322) 1:100, 90 min at 37°C; followed by conjugated Goat Anti-Rabbit IgG antibody (green ) at 37°C for 90 min, DAPI (blue) was used to stain the cell nucleus. PBS instead of the primary antibody was used as the blank control. |
| Application | IHC-P,IHC-Fr,IF,ICC/IF |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; ICC/IF: 1:50-1:200 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Chromosome; centromere; kinetochore. Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks. |
| Construction | Hybridoma Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Research Background | p53 binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, p53 binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double strand breaks. This also suggests a role in DNA repair, maintaining genomic stability. |
| Immunogen | KLH conjugated synthetic peptide: human p53BP1/53BP1 |
| Antigen Species | Human |
| Gene ID | |
| Uniprot ID |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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