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GSPT1 degrader-8
Catalog No. T215186 Copy Product Info
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GSPT1 degrader-8 is a potent, orally active molecular glue degrader of GSPT1. It induces the degradation of GSPT1 and inhibits tumor growth, making it applicable for cancer research, including studies on breast cancer.
GSPT1 degrader-8
Copy Product Info🥰Excellent
Catalog No. T215186
GSPT1 degrader-8 is a potent, orally active molecular glue degrader of GSPT1. It induces the degradation of GSPT1 and inhibits tumor growth, making it applicable for cancer research, including studies on breast cancer.
GSPT1 degrader-8
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | GSPT1 degrader-8 is a potent, orally active molecular glue degrader of GSPT1. It induces the degradation of GSPT1 and inhibits tumor growth, making it applicable for cancer research, including studies on breast cancer. |
| In vitro | GSPT1 degrader-8 (Compound 26) demonstrates inhibitory activity against HCC1569 and N87 cells, with IC50 values of 0.19 nM and 0.29 nM, respectively. At concentrations ranging from 3.3 to 300 nM over 24 hours, GSPT1 degrader-8 induces the degradation of GSPT1 in N87 cells. Western Blot AnalysisCell Line: N87 cells Concentration: 3.3, 11, 33, 100, and 300 nM Incubation Time: 24 h Result: Induced degradation of GSPT1. |
| In vivo | GSPT1 degrader-8 (Compound 26), administered orally at a dose of 30 mg/kg once daily for 17 days, effectively inhibits tumor growth in the NCI-N87 xenograft mouse model. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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You can also refer to dose conversion for different animals. More Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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