Anti-Tap1 Polyclonal Antibody is a Rabbit antibody targeting Tap1. Anti-Tap1 Polyclonal Antibody can be used in FCM.

IgG

Human (predicted:Mouse,Rat,Pig,Cow,Rabbit)

Blank control (blue): Hep G2 Cells (fixed with 2% paraformaldehyde (10 min)). Primary Antibody: Rabbit Anti-Tap1/FITC Conjugated antibody (TMAB-13374/FITC), Dilution: 1 μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG/FITC (orange), used under the same conditions.

FCM: 1μg/Test

Polyclonal

KLH conjugated synthetic peptide: human Tap1/ABCB2

Human

TAP1

Antigen peptide transporter 1

Involved in the transport of antigens from the cytoplasmto the endoplasmic reticulum for association with MHC class Imolecules. Also acts as a molecular scaffold for the final stage ofMHC class I folding, namely the binding of peptide. Nascent MHCclass I molecules associate with TAP via tapasin. Inhibited by thecovalent attachment of herpes simplex virus ICP47 protein, whichblocks the peptide-binding site of TAP. Inhibited by humancytomegalovirus US6 glycoprotein, which binds to the lumenal sideof the TAP complex and inhibits peptide translocation byspecifically blocking ATP-binding to TAP1 and prevents theconformational rearrangement of TAP induced by peptide binding.Inhibited by human adenovirus E3-19K glycoprotein, which binds theTAP complex and acts as a tapasin inhibitor, preventing MHC classI/TAP association. Expression of TAP1 is down-regulated by humanEpstein-Barr virus vIL-10 protein, thereby affecting the transportof peptides into the endoplasmic reticulum and subsequent peptideloading by MHC class I molecules.