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Kaempferol 3,4',7-triacetate

Name: Kaempferol 3,4',7-triacetate
Brand: TargetMol
SKU: TN5443
Price: 198 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN5443Cas No. 143724-69-0

Alias Kaempferol 3,4,7-triacetate, 3,7-Bis(acetyloxy)-2-[4-(acetyloxy)phenyl]-5-hydroxy-4H-1-benzopyran-4-one, 3,7,4'-Tri-O-acetylkaempferol, [4-(3,7-diacetyloxy-5-hydroxy-4-oxochromen-2-yl)phenyl] acetate

Kaempferol 3,4',7-triacetate (3,7,4'-Tri-O-acetylkaempferol) is a natural product of the herbs of Cudrania tricuspidata.

Kaempferol 3,4',7-triacetate

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Purity: 99.03%

Catalog No. TN5443Alias Kaempferol 3,4,7-triacetate, 3,7-Bis(acetyloxy)-2-[4-(acetyloxy)phenyl]-5-hydroxy-4H-1-benzopyran-4-one, 3,7,4'-Tri-O-acetylkaempferol, [4-(3,7-diacetyloxy-5-hydroxy-4-oxochromen-2-yl)phenyl] acetateCas No. 143724-69-0

Kaempferol 3,4',7-triacetate (3,7,4'-Tri-O-acetylkaempferol) is a natural product of the herbs of Cudrania tricuspidata.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$198	In Stock	In Stock
5 mg	$520	In Stock	In Stock
10 mg	$753	In Stock	In Stock
25 mg	$1,160	In Stock	-
50 mg	$1,570	In Stock	-
1 mL x 10 mM (in DMSO)	$530	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.03%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Kaempferol 3,4',7-triacetate AI Summary

Kaempferol 3,4',7-triacetate displays a variety of bioactivities, notably exhibiting toxicity in brine shrimp with an LC50 value of 2210000.0 nM after 24 hours, indicating its potential environmental impact. The compound shows significant cytotoxicity against rat L6 cells with 94.8% and 90.2% activity at concentrations of 10 uM and 1 uM, respectively, after 72 hours. Additionally, it demonstrates cytotoxicity against mouse B16 cells with an IC50 of 39800.0 nM after 48 hours. In terms of antivascular activity, Kaempferol 3,4',7-triacetate causes human EAhy926 cells to round at concentrations higher than 100.0 uM within 2 hours. The compound also has notable antiparasitic effects, including leishmanicidal activity against Leishmania amazonensis with an IC50 of 12270.0 nM after 48 hours, and modest antiplasmodial activity against Plasmodium falciparum with 7.6% growth inhibition at 10 uM after 48 hours. Lastly, it shows limited antitrypanosomal activity against Trypanosoma brucei gambiense Feo, with growth inhibitions of 5.6% at 50 uM and 0.0% at 10 uM after 72 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Kaempferol 3,4',7-triacetate (3,7,4'-Tri-O-acetylkaempferol) is a natural product of the herbs of Cudrania tricuspidata.
Synonyms	Kaempferol 3,4,7-triacetate, 3,7-Bis(acetyloxy)-2-[4-(acetyloxy)phenyl]-5-hydroxy-4H-1-benzopyran-4-one, 3,7,4'-Tri-O-acetylkaempferol, [4-(3,7-diacetyloxy-5-hydroxy-4-oxochromen-2-yl)phenyl] acetate

Chemical Properties

Molecular Weight	412.35
Formula	C₂₁H₁₆O₉
Cas No.	143724-69-0
Smiles	O(C(C)=O)C1=C(OC=2C(C1=O)=C(O)C=C(OC(C)=O)C2)C3=CC=C(OC(C)=O)C=C3
Relative Density.	1.47 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (48.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4251 mL	12.1256 mL	24.2512 mL	121.2562 mL
5 mM	0.4850 mL	2.4251 mL	4.8502 mL	24.2512 mL
10 mM	0.2425 mL	1.2126 mL	2.4251 mL	12.1256 mL
20 mM	0.1213 mL	0.6063 mL	1.2126 mL	6.0628 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc