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(R)-DNMDP

Name: (R)-DNMDP
Brand: TargetMol
SKU: T13856
Rating: 4.5 (1 reviews)

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Catalog No. T13856Cas No. 1630760-60-9

(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.

(R)-DNMDP

😃Good

Catalog No. T13856Cas No. 1630760-60-9

(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$199	6-8 weeks	6-8 weeks
5 mg	$399	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Solid

Color:Orange

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COA

Product Introduction

Bioactivity

Description	(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.
In vitro	(R)-DNMDP is a selective cancer-cytotoxic small molecule that, in large-scale cell line screening, showed low-nanomolar EC₅₀ values (10-100 nM) against multiple tumor cell lines, including HeLa, NCI-H1734, NCI-H1563, and NCI-H2122, while exhibiting no toxicity to non-sensitive cell lines such as A549, MCF7, and PC3[1].

Chemical Properties

Molecular Weight	304.34
Formula	C₁₅H₂₀N₄O₃
Cas No.	1630760-60-9
Smiles	C[C@H]1C(C2=CC([N+]([O-])=O)=C(C=C2)N(CC)CC)=NNC(C1)=O
Relative Density.	1.28 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (262.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2858 mL	16.4290 mL	32.8580 mL	164.2899 mL
5 mM	0.6572 mL	3.2858 mL	6.5716 mL	32.8580 mL
10 mM	0.3286 mL	1.6429 mL	3.2858 mL	16.4290 mL
20 mM	0.1643 mL	0.8214 mL	1.6429 mL	8.2145 mL
50 mM	0.0657 mL	0.3286 mL	0.6572 mL	3.2858 mL
100 mM	0.0329 mL	0.1643 mL	0.3286 mL	1.6429 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc