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(R)-DNMDP

Name: (R)-DNMDP
Brand: TargetMol
SKU: T13856
Rating: 4.5 (1 reviews)

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Catalog No. T13856Cas No. 1630760-60-9

(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.

(R)-DNMDP

😃Good

Catalog No. T13856Cas No. 1630760-60-9

(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$199	6-8 weeks	6-8 weeks
5 mg	$363	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.
In vitro	(R)-DNMDP is a selective cancer-cytotoxic small molecule that, in large-scale cell line screening, showed low-nanomolar EC₅₀ values (10-100 nM) against multiple tumor cell lines, including HeLa, NCI-H1734, NCI-H1563, and NCI-H2122, while exhibiting no toxicity to non-sensitive cell lines such as A549, MCF7, and PC3[1].

Chemical Properties

Molecular Weight	304.34
Formula	C₁₅H₂₀N₄O₃
Cas No.	1630760-60-9
Smiles	C[C@H]1C(C2=CC([N+]([O-])=O)=C(C=C2)N(CC)CC)=NNC(C1)=O
Relative Density.	1.28 g/cm3 (Predicted)
Color	Orange
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (262.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2858 mL	16.4290 mL	32.8580 mL	164.2899 mL
5 mM	0.6572 mL	3.2858 mL	6.5716 mL	32.8580 mL
10 mM	0.3286 mL	1.6429 mL	3.2858 mL	16.4290 mL
20 mM	0.1643 mL	0.8214 mL	1.6429 mL	8.2145 mL
50 mM	0.0657 mL	0.3286 mL	0.6572 mL	3.2858 mL
100 mM	0.0329 mL	0.1643 mL	0.3286 mL	1.6429 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc