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(2S,3R,4S)-4-Hydroxyisoleucine

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Catalog No. T2P2919Cas No. 55399-93-4
Alias Hydroxyisoleucine, (4S)-4-Hydroxy-L-isoleucine

(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesity amino acid that stimulates glucose-dependent insulin secretion from pancreatic cells, activates insulin receptor substrate-associated phosphoinositide 3 (PI3) kinase activity, and reduces plasma levels of triglycerides, free fatty acids, and cholesterol.

(2S,3R,4S)-4-Hydroxyisoleucine
Other Forms of (2S,3R,4S)-4-Hydroxyisoleucine:

(2S,3R,4S)-4-Hydroxyisoleucine

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🥰Excellent
Purity: 99.95%
Catalog No. T2P2919Alias Hydroxyisoleucine, (4S)-4-Hydroxy-L-isoleucineCas No. 55399-93-4
(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesity amino acid that stimulates glucose-dependent insulin secretion from pancreatic cells, activates insulin receptor substrate-associated phosphoinositide 3 (PI3) kinase activity, and reduces plasma levels of triglycerides, free fatty acids, and cholesterol.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 mg$31In StockIn Stock
100 mg$48In StockIn Stock
200 mg$68In StockIn Stock
500 mg$113In StockIn Stock
1 g$166In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.95%
Appearance:Solid
Color:White
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COA LCMS HNMR

Product Introduction

(2S,3R,4S)-4-Hydroxyisoleucine AI Summary
(2S,3R,4S)-4-Hydroxyisoleucine exhibits multifaceted bioactivity. In dyslipidemic male Syrian hamsters, it lowers plasma triglyceride levels by 33.0%, total cholesterol by 22.0%, free fatty acids by 14.0%, and glycerol by 4.9% at a dosage of 50 mg/kg orally, while increasing HDL-cholesterol by 8.7% and enhancing the HDL-cholesterol to total cholesterol ratio by 39.0%. In Sprague-Dawley rat pancreas, it significantly boosts insulin secretion, ranging from 45.0 pg/hr to 100.0 pg/hr per Langerhans islet. Furthermore, it shows chemical stability at pH 1 with values of 10.0% at 1 hour, 32.0% at 4 hours, and 73.0% at 20 hours. For antiviral activity, (2S,3R,4S)-4-Hydroxyisoleucine inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells with an inhibition rate of 11.94% at 10 µM after 48 hours and also shows activity against SARS-CoV-2 in VERO-6 cells with inhibition ranging from 0.0% to 0.19% in different assays. Additionally, it inhibits the SARS-CoV-2 3CL-Pro protease, with inhibition percentages of 26.4% and 0.1154% at a 20 µM concentration in different assays. The compound also inhibits human HDAC6 enzyme activity, showing -7.36% inhibition with a commercial peptide substrate and 21.36% inhibition with a custom peptide substrate, indicating potential bioactivity relevant to HDAC6 enzyme inhibition and its associated biological processes and diseases..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesity amino acid that stimulates glucose-dependent insulin secretion from pancreatic cells, activates insulin receptor substrate-associated phosphoinositide 3 (PI3) kinase activity, and reduces plasma levels of triglycerides, free fatty acids, and cholesterol.
SynonymsHydroxyisoleucine, (4S)-4-Hydroxy-L-isoleucine
Chemical Properties
Molecular Weight147.17
FormulaC6H13NO3
Cas No.55399-93-4
Smiles[C@@H]([C@@H](C(O)=O)N)([C@H](C)O)C
Relative Density.1.181 g/cm3 at 20℃
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: < 1 mg/mL (insoluble or slightly soluble)
H2O: 110 mg/mL (747.43 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM6.7949 mL33.9743 mL67.9486 mL339.7432 mL
5 mM1.3590 mL6.7949 mL13.5897 mL67.9486 mL
10 mM0.6795 mL3.3974 mL6.7949 mL33.9743 mL
20 mM0.3397 mL1.6987 mL3.3974 mL16.9872 mL
50 mM0.1359 mL0.6795 mL1.3590 mL6.7949 mL
100 mM0.0679 mL0.3397 mL0.6795 mL3.3974 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Keywords

PI3KInhibitorinhibit4-Hydroxy-L-isoleucine4-Hydroxyisoleucine(2S,3R,4S)4Hydroxyisoleucine(2S,3R,4S) 4 Hydroxyisoleucine
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