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exo-IWR-1

Name: exo-IWR-1
Brand: TargetMol
SKU: T22775
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22775Cas No. 1127442-87-8

Alias exo-IWR 1

exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.

exo-IWR-1

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Purity: 97.41%

Catalog No. T22775Alias exo-IWR 1Cas No. 1127442-87-8

exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$34	In Stock	In Stock
25 mg	$75	In Stock	In Stock
50 mg	$128	In Stock	In Stock
100 mg	$206	In Stock	In Stock
200 mg	$300	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.41%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC LCMS

Product Introduction

exo-IWR-1 AI Summary

exo-IWR-1 is a multifunctional inhibitor targeting several biological pathways and exhibiting notable bioactivity. It inhibits the Wnt3 signaling pathway by targeting the Wnt/catenin pathway with an EC50 value of 5000.0 nM, as shown in assays involving mouse L-cells. The compound also demonstrates inhibition of the N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 cells, with a similar EC50 value of 5000.0 nM. Additionally, it inhibits 6XHis-tagged tankyrase1 with an IC50 value of 1000.0 nM and significantly targets the ADP-ribosyltransferase catalytic domains of human TNKS1 and TNKS2, showing greater potency against TNKS2 (IC50 = 29.2 nM) compared to TNKS1 (IC50 = 303.0 nM). In terms of antiviral activity, exo-IWR-1 inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells at a 10 µM concentration with a 1.68% inhibition rate after 48 hours. It also shows inhibition against the SARS-CoV-2 3CL-Pro protease by 4.771% at a concentration of 20 µM. Furthermore, in VERO-6 cells, the compound exhibits a 0.12% inhibition rate at the same 10 µM concentration after 48 hours of exposure to the SARS-CoV-2 virus. Moreover, exo-IWR-1 displays inhibitory activity against human HDAC6, with an inhibition of -1.4% using a commercial peptide substrate and 4.47% using a custom peptide substrate. This compound's diverse inhibitory effects suggest potential applications in both cancer research and antiviral therapeutics..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.
Synonyms	exo-IWR 1

Chemical Properties

Molecular Weight	409.44
Formula	C₂₅H₁₉N₃O₃
Cas No.	1127442-87-8
Smiles	[H][C@@]12C[C@]([H])(C=C1)[C@@]1([H])C(=O)N(C(=O)[C@@]21[H])c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Relative Density.	1.425 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 12 mg/mL (29.31 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4424 mL	12.2118 mL	24.4236 mL	122.1180 mL
5 mM	0.4885 mL	2.4424 mL	4.8847 mL	24.4236 mL
10 mM	0.2442 mL	1.2212 mL	2.4424 mL	12.2118 mL
20 mM	0.1221 mL	0.6106 mL	1.2212 mL	6.1059 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc