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MCT1-IN-3

🥰Excellent
Catalog No. T67727Cas No. 2878360-80-4

MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor, targeting solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) for cancer treatment. MCT1-IN-3 (compound 24) showed the highest MCT1 transport inhibition with an IC50 value of 81.0 Nm and also exhibits significant inhibitory activity against the multidrug transporter ABCB1.

MCT1-IN-3

MCT1-IN-3

🥰Excellent
Purity: 99.35%
Catalog No. T67727Cas No. 2878360-80-4
MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor, targeting solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) for cancer treatment. MCT1-IN-3 (compound 24) showed the highest MCT1 transport inhibition with an IC50 value of 81.0 Nm and also exhibits significant inhibitory activity against the multidrug transporter ABCB1.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$117In StockIn Stock
5 mg$268In StockIn Stock
10 mg$395In StockIn Stock
25 mg$592In StockIn Stock
50 mg$828In StockIn Stock
100 mg$1,130-In Stock
500 mg$2,270-In Stock
1 mL x 10 mM (in DMSO)$287In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.35%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor, targeting solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) for cancer treatment. MCT1-IN-3 (compound 24) showed the highest MCT1 transport inhibition with an IC50 value of 81.0 Nm and also exhibits significant inhibitory activity against the multidrug transporter ABCB1.
Targets&IC50
MCT1:81nM
In vitro
MCT1-IN-3 has great antiproliferative activities against the MCT1-expressing cancer cell lines A-549 and MCF-7 with GI50 values of 20 μM and 15.1 μM, respectively. Treatment with MCT1-IN-3 5μM for 24 h significantly leads to cancer cell cycle arrest as well as apoptosis, which has also significant inhibitory power against the multidrug transporter ABCB1 and shows to reverse ABCB1-mediated multidrug resistance (MDR)[1].
Chemical Properties
Molecular Weight389.4
FormulaC22H19N3O4
Cas No.2878360-80-4
SmilesC(=C(C(OC)=O)C#N)C=1C=2C(N(CC(NC3=CC=C(OC)C=C3)=O)C1)=CC=CC2
Relative Density.1.22 g/cm3 (Predicted)
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 22.5 mg/mL (57.78 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5681 mL12.8403 mL25.6805 mL128.4027 mL
5 mM0.5136 mL2.5681 mL5.1361 mL25.6805 mL
10 mM0.2568 mL1.2840 mL2.5681 mL12.8403 mL
20 mM0.1284 mL0.6420 mL1.2840 mL6.4201 mL
50 mM0.0514 mL0.2568 mL0.5136 mL2.5681 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

MonocarboxylatetransporterMonocarboxylate transporterMCT1-IN-3MCT1IN3MCT1
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