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Anti-N Cadherin Antibody (3L448)
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Catalog No. TMAY-01506
Alias N-cadherin, Ncad, CDHN, cadherin 2, type 1, N-cadherin (neuronal)
Anti-N Cadherin Antibody (3L448) is a Rabbit antibody targeting N Cadherin. Anti-N Cadherin Antibody (3L448) can be used in ELISA,ICC/IF.
Anti-N Cadherin Antibody (3L448)
Anti-N Cadherin Antibody (3L448)
😃Good
Catalog No. TMAY-01506Alias N-cadherin, Ncad, CDHN, cadherin 2, type 1, N-cadherin (neuronal)
Anti-N Cadherin Antibody (3L448) is a Rabbit antibody targeting N Cadherin. Anti-N Cadherin Antibody (3L448) can be used in ELISA,ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $270 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA, ICC/IF Reactivity: Human |
| Alias | N-cadherin, Ncad, CDHN, cadherin 2, type 1, N-cadherin (neuronal) |
| Ig Type | Rabbit IgG |
| Clone | 3L448 |
| Reactivity | Human |
| Verified Activity | Immunofluorescence staining of Human CDH2 in Hela cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-Human CDH2 monoclonal antibody (1:60). Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to membrane. |
| Application | ELISA,ICC/IF |
| Recommended Dose | ELISA: 1:5000-1:10000; ICC-IF: 1:20-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human N-Cadherin / CD325 / CDH2 (rh N-Cadherin / CD325 / CDH2; NP_001783.2Met 1-Ala 724). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Cadherins are calcium-dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin 2 (CDH2), also known as N-Cadherin (neuronal) (NCAD), is a single-pass transmembrane protein and a cadherin containing 5 cadherin domains. N-Cadherin displays a ubiquitous expression pattern but with different expression levels between endocrine cell types. CDH2 (NCAD) has been shown to play an essential role in normal neuronal development, which is implicated in an array of processes including neuronal differentiation and migration, and axon growth and fasciculation. In addition, N-Cadherin expression was upregulated in human HSC during activation in culture, and function or expression blocking of N-Cadherin promoted apoptosis. During apoptosis, N-Cadherin was cleaved into 20-100 kDa fragments. It may provide a novel target for therapies that are directed toward intimal proliferative disorders, including restenosis and vascular bypass graft failure. N-Cadherin is associated with tumor aggressiveness and metastatic potential and may contribute to tumor progression. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human N-Cadherin / CD325 / CDH2 Protein (TMPY-01143) |
| Antigen Species | Human |
| Biology Area | Early Mesodermal Lineage Markers |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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