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PSN632408

Name: PSN632408
Brand: TargetMol
SKU: T16678
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: PSN-632408, PSN 632408) Copy Product Info

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Synonyms: PSN-632408, PSN 632408

Catalog No. T16678 Copy Product Info

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PSN632408 is a selective GPR119 agonist that is orally active and exhibits agonist potency comparable to that of OEA in mouse and human receptors. PSN632408 modulates pancreatic β-cell function in vitro and in animal models and may improve metabolic parameters, making it suitable for mechanistic studies of obesity and related metabolic disorders.

Cas No. 857652-30-3

Pack Size	Price	USA Stock	Global Stock	Quantity
2 mg	$51	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	PSN632408 is a selective GPR119 agonist that is orally active and exhibits agonist potency comparable to that of OEA in mouse and human receptors. PSN632408 modulates pancreatic β-cell function in vitro and in animal models and may improve metabolic parameters, making it suitable for mechanistic studies of obesity and related metabolic disorders.
Targets & IC50	CHO cells:0.63 mM (EC50), HEK293:1900 nM (EC50)
In vitro	PSN632408 produces concentration-dependent increases in cAMP level with mean EC50 value of 1.9 uM[1]. PSN632408 stimulates β cell replication in cultured mouse islets[2].
In vivo	PSN632408 (100 mg/kg; p.o.; daily for 14 days) suppresses food intake in rats and reduce body weight gain and white adipose tissue deposition upon subchronic oral administration to high-fat-fed rats[1].
Synonyms	PSN-632408, PSN 632408

Chemical Properties

Molecular Weight	360.41
Formula	C₁₈H₂₄N₄O₄
Cas No.	857652-30-3
Smiles	O=C(OC(C)(C)C)N1CCC(OCC2=NC(=NO2)C=3C=CN=CC3)CC1
Relative Density.	1.25 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (110.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (6.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7746 mL	13.8731 mL	27.7462 mL	138.7309 mL
5 mM	0.5549 mL	2.7746 mL	5.5492 mL	27.7462 mL
10 mM	0.2775 mL	1.3873 mL	2.7746 mL	13.8731 mL
20 mM	0.1387 mL	0.6937 mL	1.3873 mL	6.9365 mL
50 mM	0.0555 mL	0.2775 mL	0.5549 mL	2.7746 mL
100 mM	0.0277 mL	0.1387 mL	0.2775 mL	1.3873 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: PSN632408 chemical structure | PSN632408 in vivo | PSN632408 in vitro | PSN632408 formula | PSN632408 molecular weight