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Loperamide hydrochloride

Name: Loperamide hydrochloride
Brand: TargetMol
SKU: T0209
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0209Cas No. 34552-83-5

Alias R-18553 (hydrochloride), Loperamide HCl, ADL 2-1294

Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.

Loperamide hydrochloride

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Purity: 99.94%

Catalog No. T0209Alias R-18553 (hydrochloride), Loperamide HCl, ADL 2-1294Cas No. 34552-83-5

Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.

Pack Size	Price	Availability
50 mg	$37	In Stock
100 mg	$50	In Stock
500 mg	$77	In Stock
1 g	$109	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Purity:99.94%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.
Targets&IC50	δ opioid receptor:48 nM(Ki), μ opioid receptor:3.3 nM(Ki)
In vitro	In mice, ropivacaine cannot cross the blood-brain barrier. Subcutaneous injection of ropivacaine at the neck region (4 mg/kg) or at the site of tibial tumor mass (7.5-75 mg) can inhibit thermal hyperalgesia and mechanical allodynia.
In vivo	In human Chinese hamster ovary cells transfected with opioid receptors, Loperamide potently stimulates the binding of [35S]guanosine 5'-O-(3-thio)triphosphate (EC50=56 nM) and inhibits the accumulation of cAMP induced by forskolin (IC50=25 nM). Loperamide reversibly blocks the increase in intracellular calcium ([Ca2+]i) triggered by extracellular potassium ([K+]o) in a concentration-dependent manner (IC50=0.9 mM).
Synonyms	R-18553 (hydrochloride), Loperamide HCl, ADL 2-1294

Chemical Properties

Molecular Weight	513.50
Formula	C₂₉H₃₄Cl₂N₂O₂
Cas No.	34552-83-5
Smiles	Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1
Relative Density.	1.1905 g/cm3 (Estimated)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 99 mg/mL (192.79 mM), Sonication is recommended.

Ethanol: 10.30 mg/mL (20.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.43 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9474 mL	9.7371 mL	19.4742 mL	97.3710 mL
5 mM	0.3895 mL	1.9474 mL	3.8948 mL	19.4742 mL
10 mM	0.1947 mL	0.9737 mL	1.9474 mL	9.7371 mL
20 mM	0.0974 mL	0.4869 mL	0.9737 mL	4.8685 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0389 mL	0.1947 mL	0.3895 mL	1.9474 mL
100 mM	0.0195 mL	0.0974 mL	0.1947 mL	0.9737 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc