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GNE-140 racemate

Name: GNE-140 racemate
Brand: TargetMol
SKU: T13450L
Rating: 4.5 (1 reviews)

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Catalog No. T13450LCas No. 1802977-61-2

Alias GNE-140 (racemate)

GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.

GNE-140 racemate

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Catalog No. T13450LAlias GNE-140 (racemate)Cas No. 1802977-61-2

GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.

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Product Introduction

Bioactivity

Description	GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.
In vitro	Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme and is also a hallmark of aggressive cancers. Which believed to be the major enzyme responsible for the pyruvate-to-lactate conversion. Because of increased glycolysis, increased glucose consumption distinguishes cancer cells from normal cells and is known as the 'Warburg effect”[1].
Synonyms	GNE-140 (racemate)

Chemical Properties

Molecular Weight	499.04
Formula	C₂₅H₂₃ClN₂O₃S₂
Cas No.	1802977-61-2
Smiles	Clc1ccccc1SC1C(=O)CC(NC1=O)(c1ccsc1)c1ccc(cc1)N1CCOCC1
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 34 mg/mL (68.13 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0038 mL	10.0192 mL	20.0385 mL	100.1924 mL
5 mM	0.4008 mL	2.0038 mL	4.0077 mL	20.0385 mL
10 mM	0.2004 mL	1.0019 mL	2.0038 mL	10.0192 mL
20 mM	0.1002 mL	0.5010 mL	1.0019 mL	5.0096 mL
50 mM	0.0401 mL	0.2004 mL	0.4008 mL	2.0038 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc