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GNE-140 racemate

Name: GNE-140 racemate
Brand: TargetMol
SKU: T13450L
Rating: 4.5 (1 reviews)

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Catalog No. T13450LCas No. 1802977-61-2

Alias GNE-140 (racemate)

GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.

GNE-140 racemate

🥰Excellent

Catalog No. T13450LAlias GNE-140 (racemate)Cas No. 1802977-61-2

GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.

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Product Introduction

Bioactivity

Description	GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.
In vitro	Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme and is also a hallmark of aggressive cancers. Which believed to be the major enzyme responsible for the pyruvate-to-lactate conversion. Because of increased glycolysis, increased glucose consumption distinguishes cancer cells from normal cells and is known as the 'Warburg effect”[1].
Synonyms	GNE-140 (racemate)

Chemical Properties

Molecular Weight	499.04
Formula	C₂₅H₂₃ClN₂O₃S₂
Cas No.	1802977-61-2
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 34 mg/mL (68.13 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0038 mL	10.0192 mL	20.0385 mL	100.1924 mL
5 mM	0.4008 mL	2.0038 mL	4.0077 mL	20.0385 mL
10 mM	0.2004 mL	1.0019 mL	2.0038 mL	10.0192 mL
20 mM	0.1002 mL	0.5010 mL	1.0019 mL	5.0096 mL
50 mM	0.0401 mL	0.2004 mL	0.4008 mL	2.0038 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc