Anabaseine

Name: Anabaseine
Brand: TargetMol
SKU: T40431
Rating: 4.5 (1 reviews)

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Catalog No. T40431Cas No. 3471-05-4

Anabaseine is a non-selective nicotinic agonist that stimulates all alpha-7 subtypes of AChRs, with a preference for those in skeletal muscle and the brain. Additionally, it acts as a weak partial agonist at alpha-4 beta-2 [nAChRs].

Anabaseine

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Catalog No. T40431Cas No. 3471-05-4

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Product Introduction

Bioactivity

Description	Anabaseine is a non-selective nicotinic agonist that stimulates all alpha-7 subtypes of AChRs, with a preference for those in skeletal muscle and the brain. Additionally, it acts as a weak partial agonist at alpha-4 beta-2 [nAChRs].
In vitro	Anabaseine serves as a full agonist at the α7 AChR within the central nervous system (CNS) and operates as a full agonist for α1β1?δ and α1β1γδ (Torpedo) receptors in the peripheral nervous system. Additionally, it functions as a neuromuscular agonist on the frog rectus abdominis muscle, demonstrating efficacy within a range of EC 50 values from 0.25 to 0.74 μM.
In vivo	Anabaseine (3.6 μmol/kg; subcutaneous injection) elevates ACh levels [1].

Chemical Properties

Molecular Weight	160.22
Formula	C₁₀H₁₂N₂
Cas No.	3471-05-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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