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Anethole trithione

Name: Anethole trithione
Brand: TargetMol
SKU: T1285
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1285Cas No. 532-11-6

Alias Anetholtrithion

Anethole trithione (Anetholtrithion) is a bile secretion-stimulating drug that restores salivation and relieves the discomfort of dry mouth in chemotherapy-induced xerostomia.

Anethole trithione

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Purity: 99.65%

Catalog No. T1285Alias AnetholtrithionCas No. 532-11-6

Anethole trithione (Anetholtrithion) is a bile secretion-stimulating drug that restores salivation and relieves the discomfort of dry mouth in chemotherapy-induced xerostomia.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$31	In Stock	In Stock
50 mg	$42	In Stock	In Stock
100 mg	$58	In Stock	In Stock
500 mg	$90	-	In Stock
1 g	$128	-	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.65%

Appearance:Solid

Resource Download

COA HPLC HNMR

Product Introduction

Anethole trithione AI Summary

Anethole trithione shows a moderate to high partition coefficient (logP = 3.82), suggesting good membrane permeability. It demonstrates increased quinone reductase (Log CDQR = 1.255) and growth hormone production (Log CDGH = 1.0), indicating potential antioxidant and growth-promoting activities. The compound exhibits hepatoprotective effects in Kunming mice by reducing CCL4-induced serum ALT and AST levels at doses of 1 mg/kg, 2 mg/kg, and 4 mg/kg when administered intraperitoneally. Despite its low aqueous solubility (<10.0 µg/mL), Anethole trithione is a potent inhibitor in various assays, targeting interactions like Menin-MLL, ROR gamma transcriptional activity, HDAC6, Histone Lysine Methyltransferase G9a, and more, with inhibitory concentrations ranging from nanomolar to micromolar levels. Anethole trithione exhibits significant antiviral activity, notably against SARS-CoV-2. It inhibits cytotoxicity in VERO-6 cells and Caco-2 cells at 10 µM concentrations after 48 hours, with variable inhibition rates. Despite lower hit scores in certain assays, it shows some inhibition of the SARS-CoV-2 3CL-Pro protease and a relatively weak potency in inhibiting cytotoxicity (IC50 > 20000.0 nM). Additionally, Anethole trithione displays bioactivity relevant to drug metabolism in mouse models, affecting plasma and liver metabolism by releasing hydrogen sulfide. It is also noted for its activity against Trypanosoma cruzi TIM enzyme with an IC50 of 1200.0 nM. Overall, Anethole trithione interacts with multiple receptors, exhibiting both agonist and antagonist activities across various pathways and influencing enzyme activities, showcasing its multifaceted potential in biomedicine..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Anethole trithione (Anetholtrithion) is a bile secretion-stimulating drug that restores salivation and relieves the discomfort of dry mouth in chemotherapy-induced xerostomia.
Synonyms	Anetholtrithion

Chemical Properties

Molecular Weight	240.36
Formula	C₁₀H₈OS₃
Cas No.	532-11-6
Smiles	S=C1C=C(SS1)C2=CC=C(OC)C=C2
Relative Density.	1.4406 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (208.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1604 mL	20.8021 mL	41.6043 mL	208.0213 mL
5 mM	0.8321 mL	4.1604 mL	8.3209 mL	41.6043 mL
10 mM	0.4160 mL	2.0802 mL	4.1604 mL	20.8021 mL
20 mM	0.2080 mL	1.0401 mL	2.0802 mL	10.4011 mL
50 mM	0.0832 mL	0.4160 mL	0.8321 mL	4.1604 mL
100 mM	0.0416 mL	0.2080 mL	0.4160 mL	2.0802 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc